-transparent.png){kind=logo}
Both serotonin and histamine increased cutaneous vascular permeability in rats; however, serotonin was approximately 100-fold more potent than histamine. LY53857 (0.1 and 1.0 mg/kg, i.p.), a selective 5HT2 receptor antagonist, blocked serotonin- but not histamine-induced increases in cutaneous vascular permeability. the alpha 1 receptor antagonist, prazosin, did not significantly affect increases in vascular permeability produced by serotonin. These data extend previous studies with LY53857 by further documenting its selectivity as a 5HT2 receptor antagonist. In addition, these results with a selective 5HT2 receptor antagonist provide evidence that 5HT2 receptor activation may be the predominant mechanism associated with vascular permeability changes induced by serotonin.
M L Cohen, and
K Schenck
February 1987,
Pharmacology, biochemistry, and behavior,
M L Cohen, and
K Schenck
September 1991,
Thrombosis and haemostasis,
M L Cohen, and
K Schenck
August 1960,
Biulleten' eksperimental'noi biologii i meditsiny,
M L Cohen, and
K Schenck
June 1985,
Biological psychiatry,
M L Cohen, and
K Schenck
January 2005,
Regulatory peptides,
M L Cohen, and
K Schenck
March 1992,
The Japanese journal of psychiatry and neurology,
M L Cohen, and
K Schenck
June 1985,
Laboratory investigation; a journal of technical methods and pathology,
M L Cohen, and
K Schenck
October 1984,
European journal of pharmacology,
M L Cohen, and
K Schenck
December 1996,
Thrombosis research,
M L Cohen, and
K Schenck
September 1982,
Biochemical pharmacology,
