Transient synchronization of hippocampo-striato-thalamo-cortical networks during sleep spindle oscillations induces motor memory consolidation. 2018

Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
Unité de Neuroimagerie Fonctionnelle, C.R.I.U.G.M., Montréal, QC, Canada; Université de Montréal, Montréal, QC, Canada. Electronic address: arnaud.boutin@criugm.qc.ca.

Sleep benefits motor memory consolidation. This mnemonic process is thought to be mediated by thalamo-cortical spindle activity during NREM-stage2 sleep episodes as well as changes in striatal and hippocampal activity. However, direct experimental evidence supporting the contribution of such sleep-dependent physiological mechanisms to motor memory consolidation in humans is lacking. In the present study, we combined EEG and fMRI sleep recordings following practice of a motor sequence learning (MSL) task to determine whether spindle oscillations support sleep-dependent motor memory consolidation by transiently synchronizing and coordinating specialized cortical and subcortical networks. To that end, we conducted EEG source reconstruction on spindle epochs in both cortical and subcortical regions using novel deep-source localization techniques. Coherence-based metrics were adopted to estimate functional connectivity between cortical and subcortical structures over specific frequency bands. Our findings not only confirm the critical and functional role of NREM-stage2 sleep spindles in motor skill consolidation, but provide first-time evidence that spindle oscillations [11-17 Hz] may be involved in sleep-dependent motor memory consolidation by locally reactivating and functionally binding specific task-relevant cortical and subcortical regions within networks including the hippocampus, putamen, thalamus and motor-related cortical regions.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D008297 Male Males
D009043 Motor Activity Body movements of a human or an animal as a behavioral phenomenon. Activities, Motor,Activity, Motor,Motor Activities
D009415 Nerve Net A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction. Neural Networks (Anatomic),Nerve Nets,Net, Nerve,Nets, Nerve,Network, Neural (Anatomic),Networks, Neural (Anatomic),Neural Network (Anatomic)
D011699 Putamen The largest and most lateral of the BASAL GANGLIA lying between the lateral medullary lamina of the GLOBUS PALLIDUS and the EXTERNAL CAPSULE. It is part of the neostriatum and forms part of the LENTIFORM NUCLEUS along with the GLOBUS PALLIDUS. Nucleus Putamen,Nucleus Putamens,Putamen, Nucleus,Putamens,Putamens, Nucleus
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D005260 Female Females
D006624 Hippocampus A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation. Ammon Horn,Cornu Ammonis,Hippocampal Formation,Subiculum,Ammon's Horn,Hippocampus Proper,Ammons Horn,Formation, Hippocampal,Formations, Hippocampal,Hippocampal Formations,Hippocampus Propers,Horn, Ammon,Horn, Ammon's,Proper, Hippocampus,Propers, Hippocampus,Subiculums
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000069077 Memory Consolidation Neurological process involving the conversion of learned information into long-term memory. Consolidation, Memory,Consolidations, Memory,Memory Consolidations

Related Publications

Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
July 2016, Nature neuroscience,
Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
November 2020, Cerebral cortex (New York, N.Y. : 1991),
Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
May 2020, Philosophical transactions of the Royal Society of London. Series B, Biological sciences,
Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
October 2007, PLoS biology,
Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
June 2007, Neuroscience,
Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
January 2016, Frontiers in psychiatry,
Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
April 2016, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
October 2023, Cell reports,
Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
November 2017, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Arnaud Boutin, and Basile Pinsard, and Arnaud Boré, and Julie Carrier, and Stuart M Fogel, and Julien Doyon
August 2019, NeuroImage,
Copied contents to your clipboard!