[Level of serum inhibin B for predicting the results of testicular sperm extraction in azoospermia patients]. 2016

Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
Department of Andrology, Affiliated Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210008, China.

OBJECTIVE To investigate the value of serum inhibin B (InhB) in predicting the results of testicular sperm extraction (TESE) in patients with azoospermia. METHODS This study included 191 cases of obstructive azoospermia (OA), 360 cases of nonobstructive azoospermia (NOA), and 100 male controls with normal semen parameters. According to whether sperm was found in TESE, the NOA patients were divided into a sperm-absence group (TESE-, n=127) and a sperm-presence group (TESE+, n=233). Blood samples were collected from the subjects between 8:00 and 10:00 am for measurement of the levels of serum InhB. The specificity and sensitivity of serum InhB predicting TESE outcome were analyzed with receiver operating characteristics curve (ROC). RESULTS The serum InhB level was significantly lower in the TESE- group ([19.7±34.8] pg/ml) than in the OA ([106.8±66.2] pg/ml), TESE+ ([98.2±62.4] pg/ml) and normal control group ([108.3±65.0] pg/ml) (P<0.01), but there were no statistically significant differences among the latter three groups (P>0.05). Analysis of ROC showed that the best cut-off value of serum InhB was 19.1 pg/ml. Under the cut-off value, AUCROC was 0.88, specificity 84.2%, sensitivity 90.1%, and accuracy 88.1%. CONCLUSIONS The serum InhB level is a good and non-invasively obtained index of spermatogenesis and should be measured for predicting the results of TESE.

UI MeSH Term Description Entries
D007265 Inhibins Glycoproteins that inhibit pituitary FOLLICLE STIMULATING HORMONE secretion. Inhibins are secreted by the Sertoli cells of the testes, the granulosa cells of the ovarian follicles, the placenta, and other tissues. Inhibins and ACTIVINS are modulators of FOLLICLE STIMULATING HORMONE secretions; both groups belong to the TGF-beta superfamily, as the TRANSFORMING GROWTH FACTOR BETA. Inhibins consist of a disulfide-linked heterodimer with a unique alpha linked to either a beta A or a beta B subunit to form inhibin A or inhibin B, respectively Female Inhibin,Inhibin,Inhibin-F,Inhibins, Female,Inhibins, Testicular,Ovarian Inhibin,Testicular Inhibin,Female Inhibins,Inhibin F,Inhibin, Female,Inhibin, Ovarian,Inhibin, Testicular,Testicular Inhibins
D008297 Male Males
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012372 ROC Curve A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli. ROC Analysis,Receiver Operating Characteristic,Analysis, ROC,Analyses, ROC,Characteristic, Receiver Operating,Characteristics, Receiver Operating,Curve, ROC,Curves, ROC,ROC Analyses,ROC Curves,Receiver Operating Characteristics
D012661 Semen The thick, yellowish-white, viscid fluid secretion of male reproductive organs discharged upon ejaculation. In addition to reproductive organ secretions, it contains SPERMATOZOA and their nutrient plasma. Seminal Plasma,Plasma, Seminal
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D013091 Spermatogenesis The process of germ cell development in the male from the primordial germ cells, through SPERMATOGONIA; SPERMATOCYTES; SPERMATIDS; to the mature haploid SPERMATOZOA. Spermatocytogenesis,Spermiogenesis
D013094 Spermatozoa Mature male germ cells derived from SPERMATIDS. As spermatids move toward the lumen of the SEMINIFEROUS TUBULES, they undergo extensive structural changes including the loss of cytoplasm, condensation of CHROMATIN into the SPERM HEAD, formation of the ACROSOME cap, the SPERM MIDPIECE and the SPERM TAIL that provides motility. Sperm,Spermatozoon,X-Bearing Sperm,X-Chromosome-Bearing Sperm,Y-Bearing Sperm,Y-Chromosome-Bearing Sperm,Sperm, X-Bearing,Sperm, X-Chromosome-Bearing,Sperm, Y-Bearing,Sperm, Y-Chromosome-Bearing,Sperms, X-Bearing,Sperms, X-Chromosome-Bearing,Sperms, Y-Bearing,Sperms, Y-Chromosome-Bearing,X Bearing Sperm,X Chromosome Bearing Sperm,X-Bearing Sperms,X-Chromosome-Bearing Sperms,Y Bearing Sperm,Y Chromosome Bearing Sperm,Y-Bearing Sperms,Y-Chromosome-Bearing Sperms
D013737 Testis The male gonad containing two functional parts: the SEMINIFEROUS TUBULES for the production and transport of male germ cells (SPERMATOGENESIS) and the interstitial compartment containing LEYDIG CELLS that produce ANDROGENS. Testicles,Testes,Testicle
D053625 Sperm Retrieval Procedures to obtain viable sperm from the male reproductive tract, including the TESTES, the EPIDIDYMIS, or the VAS DEFERENS. Epididymal Sperm Aspiration,Epididymal Sperm Retrieval,Sperm Aspiration,Testicular Sperm Aspiration,Testicular Sperm Retrieval,Vasal Sperm Aspiration,Vasal Sperm Retrieval,Sperm Aspiration, Epididymal,Sperm Aspiration, Testicular,Sperm Aspiration, Vasal,Sperm Retrieval, Epididymal,Sperm Retrieval, Testicular,Sperm Retrieval, Vasal,Sperm Retrievals

Related Publications

Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
April 2002, Human reproduction (Oxford, England),
Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
August 2000, Human reproduction (Oxford, England),
Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
January 2006, International urology and nephrology,
Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
October 2005, The journal of obstetrics and gynaecology research,
Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
December 2005, Reproductive medicine and biology,
Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
December 2002, Fertility and sterility,
Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
October 2009, The Journal of urology,
Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
December 2019, Andrologia,
Liang Shi, and Wei-Wei Li, and Xue Zhou, and Zhi-Peng Xu, and Chun-Hua Zhang
December 2020, Human reproduction (Oxford, England),
Copied contents to your clipboard!