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Persistent induction of goblet cell differentiation in the airways: Therapeutic approaches. 2018
Andrew T Reid, and
Punnam Chander Veerati, and
Reinoud Gosens, and
Nathan W Bartlett, and
Peter A Wark, and
Chris L Grainge, and
Stephen M Stick, and
Anthony Kicic, and
Fatemeh Moheimani, and
Philip M Hansbro, and
Darryl A Knight
School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New South Wales, Australia. Electronic address: Andrew.reid@newcastle.edu.au.
Dysregulated induction of goblet cell differentiation results in excessive production and retention of mucus and is a common feature of several chronic airways diseases. To date, therapeutic strategies to reduce mucus accumulation have focused primarily on altering the properties of the mucus itself, or have aimed to limit the production of mucus-stimulating cytokines. Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation and highlights both pre-existing and novel therapeutic strategies to combat this pathology.
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