Biomaterial Database

Healing of experimentally produced round window membrane rupture. 1989

K Gyo

Department of Otolaryngology, Ehime University, Japan.

The healing mechanism of experimentally produced ruptures of the round window was histologically studied in guinea pigs. Surgically created rupture of the round window resulted in spontaneous closure within 2 weeks. Light microscopical examination indicated that the rupture closed with proliferation of connective tissue which usually appeared to protrude into the middle ear cavity, each case showing a unique shape. In one case, the wound was covered with granulation tissue at the site of closure on the middle ear surface. Although the rupture was closed by connective tissue, the elastic fibres of the middle layer remained disrupted at the early stage of healing.

UI	MeSH Term	Description	Entries
D003051	Cochlea	The part of the inner ear (LABYRINTH) that is concerned with hearing. It forms the anterior part of the labyrinth, as a snail-like structure that is situated almost horizontally anterior to the VESTIBULAR LABYRINTH.	Cochleas
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012405	Round Window, Ear	Fenestra of the cochlea, an opening in the basal wall between the MIDDLE EAR and the INNER EAR, leading to the cochlea. It is closed by a secondary tympanic membrane.	Cochlear Round Window,Fenestra Cochleae,Round Window of Ear,Cochlear Round Windows,Ear Round Window,Round Window, Cochlear,Round Windows, Cochlear,Round Windows, Ear
D012421	Rupture	Forcible or traumatic tear or break of an organ or other soft part of the body.	Ruptures
D014945	Wound Healing	Restoration of integrity to traumatized tissue.	Healing, Wound,Healings, Wound,Wound Healings