-transparent.png){kind=logo}
Hyperammonemia is a major contributing factor to the neurological abnormalities observed in hepatic encephalopathy and in congenital defects of ammonia detoxication. In rats variable changes in labile energy rich phosphates in the brain have been observed in hyperammonemia using biochemical methods. Using 31P-NMR spectroscopy however no significant changes of the relative concentrations of the energy rich phosphates alpha, beta and gamma-ATP, phosphocreatine, inorganic phosphate and the pH were found in the fronto parietal cortex of the urease treated hyperammonemic rat. Alterations in the metabolites of these compounds do not appear to be a major pathomechanism of ammonia toxicity in this brain area.
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
January 1987,
Magnetic resonance in medicine,
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
March 1992,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
January 1992,
Magnetic resonance in medicine,
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
April 1986,
Journal of neuroscience methods,
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
April 1985,
Journal of neurochemistry,
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
December 1989,
The American journal of physiology,
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
September 1989,
Journal of anesthesia,
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
September 1992,
The American journal of physiology,
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
July 1986,
Cancer biochemistry biophysics,
R Friolet, and
J P Colombo, and
F Lazeyras, and
W P Aue, and
R Kretschmer, and
A Zimmermann, and
C Bachmann
May 1995,
Biochemical Society transactions,
