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A transient rise in intracellular free Ca2+ concentration ([Ca2+]i) has been implicated in mitogenic induction of cell division. Individual human foreskin fibroblasts in confluent cultures examined with the Ca2+ indicator Fura-2 and a fluorescence microscope-imaging system had a basal [Ca2+]i which varied markedly from cell-to-cell. A transient serum-induced rise in [Ca2+]i was demonstrated the magnitude of which was directly correlated with the basal [Ca2+]i level. In contrast to serum-induced increase in [Ca2+]i, exposure to an elevated level of extracellular Ca2+, which is at least equally mitogenic for fibroblasts, did not alter the basal [Ca2+]i of single subconfluent cells or confluent cells. Elevated extracellular Ca2+ does not exert its mitogenicity via a transient rise in [Ca2+]i.
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
June 1998,
Brain research,
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
June 2001,
Neurological research,
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
December 1993,
British journal of pharmacology,
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
January 1992,
Agents and actions. Supplements,
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
November 1988,
Pflugers Archiv : European journal of physiology,
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
January 2007,
Journal of receptor and signal transduction research,
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
July 1971,
American journal of diseases of children (1960),
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
December 2018,
Proceedings of the National Academy of Sciences of the United States of America,
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
January 1991,
The Journal of biological chemistry,
F C Praeger, and
L Reinlib, and
M Donowitz, and
B A Gilchrest
September 1986,
The Journal of biological chemistry,
