Explore the effects of Huang-Lian-Jie-Du-Tang on Alzheimer's disease by UPLC-QTOF/MS-based plasma metabolomics study. 2018

Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
State Key Laboratory of Natural Medicines, Department of Chinese Medicines Analysis, China Pharmaceutical University, Nanjing, 210009, China; Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, 210023, China.

Alzheimer's disease (AD) is a progressive neurodegenerative disease with neither definitive pathogenesis nor effective treatment method so far. Huang-Lian-Jie-Du-Tang (HLJDT) is a classic formula of traditional Chinese medicine (TCM) proven to have ameliorative effects on learning and memory deficits of dementia. Morris water maze (MWM) test and pathology analysis have demonstrated that HLJDT could ameliorate learning and memory deficits in AD mouse model, which may act via its anti-neuroinflammation properties. According to our previous studies, an UPLC-QTOF/MS-based metabolomics approach was performed to explore the potential mechanisms of HLJDT on preventing AD. As a result, a total of 23 potential metabolites (VIP >1, |Pcorr| >0.58, CUFjk excludes 0, P < 0.05) contributing to AD progress were identified. The metabolic pathway analysis with MetPA revealed that glycerophospholipid metabolism, sphingolipid metabolism, arachidonic acid metabolism, linoleic acid metabolism and tryptophan metabolism were disturbed in mouse model of AD. After HLJDT treatment, 14 metabolites were restored back to the control-like levels.

UI MeSH Term Description Entries
D008297 Male Males
D008516 Medicine, Chinese Traditional A system of traditional medicine which is based on the beliefs and practices of the Chinese culture. Chinese Medicine, Traditional,Chung I Hsueh,Traditional Medicine, Chinese,Zhong Yi Xue,Chinese Traditional Medicine,Traditional Chinese Medicine,Traditional Tongue Assessment,Traditional Tongue Diagnosis,Hsueh, Chung I,Tongue Assessment, Traditional,Tongue Diagnoses, Traditional,Tongue Diagnosis, Traditional,Traditional Tongue Assessments,Traditional Tongue Diagnoses
D008822 Mice, Transgenic Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN. Transgenic Mice,Founder Mice, Transgenic,Mouse, Founder, Transgenic,Mouse, Transgenic,Mice, Transgenic Founder,Transgenic Founder Mice,Transgenic Mouse
D011897 Random Allocation A process involving chance used in therapeutic trials or other research endeavor for allocating experimental subjects, human or animal, between treatment and control groups, or among treatment groups. It may also apply to experiments on inanimate objects. Randomization,Allocation, Random
D002851 Chromatography, High Pressure Liquid Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed. Chromatography, High Performance Liquid,Chromatography, High Speed Liquid,Chromatography, Liquid, High Pressure,HPLC,High Performance Liquid Chromatography,High-Performance Liquid Chromatography,UPLC,Ultra Performance Liquid Chromatography,Chromatography, High-Performance Liquid,High-Performance Liquid Chromatographies,Liquid Chromatography, High-Performance
D004365 Drugs, Chinese Herbal Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China. Chinese Herbal Drugs,Plant Extracts, Chinese,Chinese Drugs, Plant,Chinese Plant Extracts,Extracts, Chinese Plant,Herbal Drugs, Chinese
D000544 Alzheimer Disease A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57) Acute Confusional Senile Dementia,Alzheimer's Diseases,Dementia, Alzheimer Type,Dementia, Senile,Presenile Alzheimer Dementia,Senile Dementia, Alzheimer Type,Alzheimer Dementia,Alzheimer Disease, Early Onset,Alzheimer Disease, Late Onset,Alzheimer Sclerosis,Alzheimer Syndrome,Alzheimer Type Senile Dementia,Alzheimer's Disease,Alzheimer's Disease, Focal Onset,Alzheimer-Type Dementia (ATD),Dementia, Presenile,Dementia, Primary Senile Degenerative,Early Onset Alzheimer Disease,Familial Alzheimer Disease (FAD),Focal Onset Alzheimer's Disease,Late Onset Alzheimer Disease,Primary Senile Degenerative Dementia,Senile Dementia, Acute Confusional,Alzheimer Dementias,Alzheimer Disease, Familial (FAD),Alzheimer Diseases,Alzheimer Type Dementia,Alzheimer Type Dementia (ATD),Alzheimers Diseases,Dementia, Alzheimer,Dementia, Alzheimer-Type (ATD),Familial Alzheimer Diseases (FAD),Presenile Dementia,Sclerosis, Alzheimer,Senile Dementia
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D016896 Treatment Outcome Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series. Rehabilitation Outcome,Treatment Effectiveness,Clinical Effectiveness,Clinical Efficacy,Patient-Relevant Outcome,Treatment Efficacy,Effectiveness, Clinical,Effectiveness, Treatment,Efficacy, Clinical,Efficacy, Treatment,Outcome, Patient-Relevant,Outcome, Rehabilitation,Outcome, Treatment,Outcomes, Patient-Relevant,Patient Relevant Outcome,Patient-Relevant Outcomes
D051379 Mice The common name for the genus Mus. Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus

Related Publications

Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
January 2021, Journal of pharmaceutical and biomedical analysis,
Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
September 2012, Journal of ethnopharmacology,
Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
May 2004, Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials,
Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
January 2013, Evidence-based complementary and alternative medicine : eCAM,
Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
May 2017, AAPS PharmSciTech,
Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
July 2013, Phytomedicine : international journal of phytotherapy and phytopharmacology,
Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
December 2013, Journal of ethnopharmacology,
Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
January 2020, Evidence-based complementary and alternative medicine : eCAM,
Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
January 2014, Journal of pharmaceutical and biomedical analysis,
Li-Min Sun, and Bao-Jie Zhu, and Hui-Ting Cao, and Xin-Yi Zhang, and Qi-Chun Zhang, and Gui-Zhong Xin, and Lin-Mei Pan, and Li-Fang Liu, and Hua-Xu Zhu
September 2008, Journal of ethnopharmacology,
Copied contents to your clipboard!