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4-Hydroperoxycyclophosphamide (4-OOH-CYP) is spontaneously converted in aqueous solution to 4-hydroxycyclophosphamide (4-OH-CYP), the major active metabolic of cyclophosphamide. We studied the dose related effects of in vitro treatment with 4-OOH-CYP on human T- and B cell-mediated immune responses. T-cell proliferation to mitogens and alloantigens was only partially inhibited even relatively high-doses of 4-OOH-CYP (greater than 6-12 micrograms/ml). In contrast cytotoxic functions of activated T-cells and natural killer (NK) cells were inhibited at lower doses (3-6 micrograms/ml). PWM induced in vitro synthesis of IgG by B-cells was inhibited at less than 3 micrograms/ml of 4-OOH-CYP. These data indicate that 4-HOO-CYP has selective, dose-dependent effects on human T and B cells in vitro.
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
January 1982,
The Journal of experimental medicine,
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
January 1984,
Cancer immunology, immunotherapy : CII,
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
December 1986,
Teratology,
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
September 1984,
Cancer research,
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
September 1987,
Methods and findings in experimental and clinical pharmacology,
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
March 1989,
Journal of immunology (Baltimore, Md. : 1950),
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
March 1990,
Cancer research,
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
February 1994,
European journal of immunology,
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
March 1985,
Blood,
H Kodo, and
B Bonavida, and
M Colvin, and
R P Gale
October 1989,
The Tohoku journal of experimental medicine,
