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ATP-ase activity in mitochondria isolated from liver needle-biopsy samples was measured in 5 diabetics, aged 30-63 years and in 4 control subjects of similar age. The mitochondrial fraction was isolated by differential centrifugation of the homogenate and the ATP-ase activity was determined in the optimal conditions previously described for human liver mitochondria. The basal and Mg-stimulated ATP-ase activities were higher, while the DNP-stimulated ATP-ase activity was lower in diabetics compared to controls. The ratio of DNP-ATP-ase/Mg2+-ATP-ase was between 1-2 in diabetics and above 5 in controls. This pattern of ATP-ase activity in diabetics is indicative of mitochondrial damage. No quantitative changes in the amount of mitochondria isolated from liver (expressed in micrograms mitochondrial protein/mg wet tissue) could be noticed in diabetics compared to controls. Consequently, the alterations of ATP-ase activity is probably reflective of impairments of functional integrity of liver mitochondria in diabetics.
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
March 1955,
The Journal of biophysical and biochemical cytology,
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
September 1950,
The Biochemical journal,
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
December 1963,
Il Fegato,
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
November 2010,
Biochemical and biophysical research communications,
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
December 2002,
Analytical biochemistry,
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
June 1973,
Endokrinologie,
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
January 1969,
Voprosy meditsinskoi khimii,
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
February 1984,
Clinical science (London, England : 1979),
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
January 1965,
Histochemie. Histochemistry. Histochimie,
A Duţu, and
V Borza, and
N Mosora, and
M Motocu, and
G Benga
September 1970,
Biochemical and biophysical research communications,
