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Resveratrol (RESV), an antifungal compound from grapes and other plants, has a distinct ability to inhibit the Chlamydia (C.) trachomatis developmental cycle in McCoy cells, a classic cell line used for chlamydial research. Inoculation of C. trachomatis with increasing amounts of RESV (from 12.5 to 100 μM) gave a dose-dependent reduction in the number of infected McCoy cells visualized by using monoclonal antibodies against chlamydial lipopolysaccharide. A similar trend has been observed with immunoassay for major outer membrane protein (MOMP). Furthermore, there was a step-wise reduction in the number of C. trachomatis infective progenies caused by the increasing concentrations of RESV. The ability of RESV to arrest C. trachomatis growth in McCoy cells was confirmed by a nucleic acid amplification protocol which revealed dose-dependent changes in mRNAs for different genes of chlamydial developmental cycle (euo, incA, and omcB). Although the precise nature of the antichlamydial activity of RESV is yet to be determined and evaluated in future studies, the observed effect of RESV on C. trachomatis infection was not related to its potential effect on attachment/entry of the pathogen into eukaryotic cells or RESV toxicity to McCoy cells. Similar inhibitory effect was shown for C. pneumoniae and C. muridarum.
Ivan M Petyaev, and
Nayilia A Zigangirova, and
Elena Y Morgunova, and
Nigel H Kyle, and
Elena D Fedina, and
Yuriy K Bashmakov
October 1977,
Journal of clinical microbiology,
Ivan M Petyaev, and
Nayilia A Zigangirova, and
Elena Y Morgunova, and
Nigel H Kyle, and
Elena D Fedina, and
Yuriy K Bashmakov
January 1974,
Medical laboratory technology,
Ivan M Petyaev, and
Nayilia A Zigangirova, and
Elena Y Morgunova, and
Nigel H Kyle, and
Elena D Fedina, and
Yuriy K Bashmakov
June 1988,
Infection and immunity,
Ivan M Petyaev, and
Nayilia A Zigangirova, and
Elena Y Morgunova, and
Nigel H Kyle, and
Elena D Fedina, and
Yuriy K Bashmakov
April 1982,
Experimental and molecular pathology,
Ivan M Petyaev, and
Nayilia A Zigangirova, and
Elena Y Morgunova, and
Nigel H Kyle, and
Elena D Fedina, and
Yuriy K Bashmakov
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Applied microbiology,
Ivan M Petyaev, and
Nayilia A Zigangirova, and
Elena Y Morgunova, and
Nigel H Kyle, and
Elena D Fedina, and
Yuriy K Bashmakov
September 1978,
Infection and immunity,
Ivan M Petyaev, and
Nayilia A Zigangirova, and
Elena Y Morgunova, and
Nigel H Kyle, and
Elena D Fedina, and
Yuriy K Bashmakov
September 2000,
Infection and immunity,
Ivan M Petyaev, and
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Nigel H Kyle, and
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Yuriy K Bashmakov
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Infection,
Ivan M Petyaev, and
Nayilia A Zigangirova, and
Elena Y Morgunova, and
Nigel H Kyle, and
Elena D Fedina, and
Yuriy K Bashmakov
January 1987,
Sexually transmitted diseases,
Ivan M Petyaev, and
Nayilia A Zigangirova, and
Elena Y Morgunova, and
Nigel H Kyle, and
Elena D Fedina, and
Yuriy K Bashmakov
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