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The efficacy and safety of baclofen (30-80 mg daily) for the treatment of acute low-back syndrome were evaluated in a 14-day, double-blind, randomized study of 200 patients (100 baclofen, 100 placebo). Patients with initially severe or extremely severe symptoms (as opposed to moderate symptoms) benefitted most from treatment with baclofen. The incidence of adverse effects was significantly higher in the baclofen group; however, most were mild to moderate and disappeared in all but two patients who required a reduction in dosage, without reduced drug efficacy. Baclofen was shown to be effective, safe, and well-tolerated for the treatment of patients with acute low-back syndrome.
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
March 2001,
Neurology,
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
June 1987,
Spine,
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
August 2010,
Photomedicine and laser surgery,
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
April 2014,
Acupuncture in medicine : journal of the British Medical Acupuncture Society,
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
October 1976,
Acta psychiatrica Scandinavica,
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
March 1997,
The American journal of otology,
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
November 1996,
The American journal of otology,
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
January 1982,
Clinical therapeutics,
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
January 2018,
The American journal of gastroenterology,
F Dapas, and
S F Hartman, and
L Martinez, and
B E Northrup, and
R T Nussdorf, and
H M Silberman, and
H Gross
October 1995,
Neurology,
