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In order to reveal the activity of polymorphonuclear neutrophil leukocytes (PMNL) representing the first step of defence against infections, measurements of chemiluminescence (CL) were performed in patients suffering from acquired immune deficiency syndrome (AIDS), lymphadenopathy, or hemophilia. In comparison with healthy controls, AIDS patients revealed significant reduction (about 50 per cent) of phagocytic, i.e. CL activity of neutrophils, which had been induced by Zymosan. Only part of the patients suffering from lymphadenopathy answered with decreased granulocyte activity on the application of Zymosan. If concanavalin A was used as stimulant of metabolic activity of PMNL-independently of phagocytosis-again AIDS and some of the lymphadenopathy patients showed a markedly reduced neutrophil response. In conclusion it should be stated that there is some evidence for at least two defects of cellular immunity associated with AIDS and to some extent, with AIDS-endangered homosexuals suffering from lymphadenopathy: first the defect of PMNL to answer to concanavalin A with increased metabolic activity, and secondly the defect of PMNL to start phagocytosis induced by Zymosan with a subsequent release of oxygen radicals which are measurable as chemiluminescence. The appraisal of granulocyte activity by means of measurements of chemiluminescence might become an additional criterion for AIDS diagnostics.
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
January 1984,
Scandinavian journal of haematology. Supplementum,
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
July 1987,
Kangogaku zasshi,
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
March 1986,
The British journal of surgery,
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
September 1984,
Lancet (London, England),
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
November 1987,
Dental Cadmos,
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
April 1985,
Australian and New Zealand journal of medicine,
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
January 1989,
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis,
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
October 1987,
The New England journal of medicine,
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
January 1989,
Immunology series,
L Stöhr, and
P Altmeyer, and
M J Sessler, and
I Scharrer, and
E B Helm, and
H Holzmann
January 1991,
Antibiotics and chemotherapy,
