-transparent.png){kind=logo}
Previous studies have shown that rates of ethanol metabolism increase markedly 2-4 hr after the administration of ethanol in rats and in four inbred strains of mice. This phenomenon, called the swift increase in alcohol metabolism (SIAM), also exists in humans. To determine whether alcohol dehydrogenase (ADH) is necessary for the SIAM response, we compared ethanol metabolism in two strains of the deer mouse, Peromyscus maniculatus. One strain lacks alcohol dehydrogenase (ADH-negative), whereas the other strain has normal ADH levels (ADH-positive). Rates of ethanol elimination were determined after a single intraperitoneal injection of ethanol at different doses (0.5 to 3.0 g/kg) and also after both strains were exposed to various levels of ethanol vapor for 4 hr. The ADH-positive strain exhibited up to a 72% increase in the rate of ethanol elimination after exposure to ethanol vapor compared to the ethanol-injected controls. In contrast, treatment with ethanol vapor did not alter rates of ethanol elimination in the ADH-negative strain. These data demonstrate clearly that ADH is required for SIAM in the deer mouse. In addition, in both the ADH-positive and the ADH-negative strain, rates of ethanol elimination increased in both the ethanol-injected and vapor-treated groups 2- to 3-fold as the dose of ethanol was increased from 100 to 500 mg/100 ml. Thus, it is concluded that this "concentration effect" of ethanol on rates of ethanol metabolism does not involve ADH in the . deer mouse.
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
January 1983,
Pharmacology, biochemistry, and behavior,
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
January 1980,
Advances in experimental medicine and biology,
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
January 2005,
Alcohol (Fayetteville, N.Y.),
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
January 1979,
Currents in alcoholism,
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
January 1981,
Currents in alcoholism,
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
June 2007,
Journal of gastroenterology and hepatology,
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
August 1991,
Archives of biochemistry and biophysics,
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
August 1989,
Alcoholism, clinical and experimental research,
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
July 1982,
Biochemical pharmacology,
E B Glassman, and
G A McLaughlin, and
D T Forman, and
M R Felder, and
R G Thurman
January 1988,
Annals of clinical and laboratory science,
