Biomaterial Database

Rheumatoid arthritis: IFNγ drives synovial tissue remodelling. 2018

Jessica McHugh

UI	MeSH Term	Description	Entries
D005347	Fibroblasts	Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.	Fibroblast
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000070918	Synoviocytes	Cells on the luminal surface of the SYNOVIAL MEMBRANE. Type A synoviocytes are MACROPHAGES responsible for waste removal from the joint cavity. Fibroblast-like type B synoviocytes are involved in production of joint matrix constituents (e.g., HYALURONAN; COLLAGEN; and FIBRONECTIN).	Synoviocyte
D001172	Arthritis, Rheumatoid	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.	Rheumatoid Arthritis
D013583	Synovial Membrane	The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.	Synovium,Membrana Synovialis Capsulae Articularis,Membrane, Synovial,Membranes, Synovial,Synovial Membranes
D053612	Janus Kinases	A family of intracellular tyrosine kinases that participate in the signaling cascade of cytokines by associating with specific CYTOKINE RECEPTORS. They act upon STAT TRANSCRIPTION FACTORS in signaling pathway referred to as the JAK/STAT pathway. The name Janus kinase refers to the fact the proteins have two phosphate-transferring domains.	Janus Kinase,JAK Kinases,Kinase, Janus,Kinases, JAK,Kinases, Janus