BIOMAT Database Logo BIOMAT Database Logo

Phylogenetic analysis reveals three distinct epidemiological profiles in Dutch and Flemish blood donors with hepatitis B virus infection. 2018

Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
Department op Blood-borne Infections, Sanquin Research, Amsterdam, The Netherlands. Electronic address: tjw.laar@sanquin.nl.

During 2006-2016, hepatitis B virus (HBV) was detected in nearly 400 blood donors in the Netherlands and Flanders. Donor demographics and self-reported risk factors as disclosed during the donor exit interview were compared to HBV phylogenies of donor and reference sequences. First-time donors with chronic HBV-infection were often immigrants (67%) infected with genetically highly diverse strains of genotypes A (32%), B (8%), C (6%), D (53%) and E to H (1%). Each subtype was strongly associated with donor ethnicity. In contrast, 57/62 (93%) of acute/recent HBV infections occurred among indigenous donors, of whom 67% was infected with one specific widely circulating epidemic HBV-A2 lineage. HBV typing identified three distinct epidemiological profiles: the import of chronic HBV infections through migration, longstanding transmission of non-epidemic HBV-A2 strains within western-Europe, and the active transmission of one epidemic HBV-A2 strain most likely fueled by sexual risk behavior.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009426 Netherlands Country located in EUROPE. It is bordered by the NORTH SEA, BELGIUM, and GERMANY. Constituent areas are Aruba, Curacao, and Sint Maarten, formerly included in the NETHERLANDS ANTILLES. Holland,Kingdom of the Netherlands
D010802 Phylogeny The relationships of groups of organisms as reflected by their genetic makeup. Community Phylogenetics,Molecular Phylogenetics,Phylogenetic Analyses,Phylogenetic Analysis,Phylogenetic Clustering,Phylogenetic Comparative Analysis,Phylogenetic Comparative Methods,Phylogenetic Distance,Phylogenetic Generalized Least Squares,Phylogenetic Groups,Phylogenetic Incongruence,Phylogenetic Inference,Phylogenetic Networks,Phylogenetic Reconstruction,Phylogenetic Relatedness,Phylogenetic Relationships,Phylogenetic Signal,Phylogenetic Structure,Phylogenetic Tree,Phylogenetic Trees,Phylogenomics,Analyse, Phylogenetic,Analysis, Phylogenetic,Analysis, Phylogenetic Comparative,Clustering, Phylogenetic,Community Phylogenetic,Comparative Analysis, Phylogenetic,Comparative Method, Phylogenetic,Distance, Phylogenetic,Group, Phylogenetic,Incongruence, Phylogenetic,Inference, Phylogenetic,Method, Phylogenetic Comparative,Molecular Phylogenetic,Network, Phylogenetic,Phylogenetic Analyse,Phylogenetic Clusterings,Phylogenetic Comparative Analyses,Phylogenetic Comparative Method,Phylogenetic Distances,Phylogenetic Group,Phylogenetic Incongruences,Phylogenetic Inferences,Phylogenetic Network,Phylogenetic Reconstructions,Phylogenetic Relatednesses,Phylogenetic Relationship,Phylogenetic Signals,Phylogenetic Structures,Phylogenetic, Community,Phylogenetic, Molecular,Phylogenies,Phylogenomic,Reconstruction, Phylogenetic,Relatedness, Phylogenetic,Relationship, Phylogenetic,Signal, Phylogenetic,Structure, Phylogenetic,Tree, Phylogenetic
D001782 Blood Donors Individuals supplying blood or blood components for transfer to histocompatible recipients. Blood Donor,Donor, Blood,Donors, Blood
D005260 Female Females
D005838 Genotype The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS. Genogroup,Genogroups,Genotypes
D006509 Hepatitis B INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact. Hepatitis B Virus Infection
D006515 Hepatitis B virus The type species of the genus ORTHOHEPADNAVIRUS which causes human HEPATITIS B and is also apparently a causal agent in human HEPATOCELLULAR CARCINOMA. The Dane particle is an intact hepatitis virion, named after its discoverer. Non-infectious spherical and tubular particles are also seen in the serum. Dane Particle,Hepatitis Virus, Homologous Serum,B virus, Hepatitis,Hepatitis B viruses,Particle, Dane,viruses, Hepatitis B
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
Diversity and origin of hepatitis B virus in Dutch blood donors.
May 2004, Journal of medical virology,
Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
First epidemiological and phylogenetic analysis of Hepatitis B virus infection in migrants from Mali.
April 2017, Journal of medical virology,
Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
An epidemiological study of hepatitis B virus amongst blood donors.
March 1989, The Journal of communicable diseases,
Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
Usutu virus infection in Dutch blood donors.
September 2019, Transfusion,
Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
[Investigation of hepatitis B virus infection in blood donors].
January 1998, Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University,
Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
Occult hepatitis B virus infection in Thai blood donors.
July 2011, Transfusion,
Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
Occult Hepatitis B Virus Infection in Nigerian Blood Donors and Hepatitis B Virus Transmission Risks.
January 2015, PloS one,
Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
Silent hepatitis E virus infection in Dutch blood donors, 2011 to 2012.
August 2013, Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin,
Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
[Asymptomatic infection with virus B hepatitis in blood donors--current problems].
November 1975, Polski tygodnik lekarski (Warsaw, Poland : 1960),
Thijs J van de Laar, and Véronique A Van Gaever, and Peter van Swieten, and An Muylaert, and Veerle Compernolle, and Hans L Zaaijer
Occult hepatitis B virus infection among Egyptian blood donors.
February 2013, World journal of hepatology,
Copied contents to your clipboard!