-transparent.png){kind=logo}
Atrial natriuretic factor (ANF), a recently sequenced cardiac peptide, has been shown to have potent natriuretic, diuretic, and vasodilating effects in several species. We have developed a radioimmunoassay to measure the levels of immunoreactive ANF in human plasma. Plasma levels of ANF in healthy volunteers on a low sodium diet were 9.8 +/- 1.4 pmol/liter and increased to 21.9 +/- 3.0 on a high sodium diet. The levels of atrial natriuretic factor correlated directly with urinary sodium and inversely with plasma renin activity and plasma aldosterone levels. Patients with marked edema due to congestive heart failure had plasma levels of atrial natriuretic factor five times higher than normal (P less than 0.05), whereas patients with cirrhosis and edema had levels that were not different from normal. These results suggest that atrial natriuretic factor plays an important role in the adaptation to increased sodium intake.
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
November 1986,
American heart journal,
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
November 1986,
Regulatory peptides,
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
December 1988,
Clinical nephrology,
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
February 1993,
European heart journal,
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
May 1985,
Biochemical and biophysical research communications,
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
June 1987,
The American journal of physiology,
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
January 1990,
Annals of clinical biochemistry,
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
April 1993,
Archives des maladies du coeur et des vaisseaux,
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
October 1990,
Clinica chimica acta; international journal of clinical chemistry,
Y Shenker, and
R S Sider, and
E A Ostafin, and
R J Grekin
October 1985,
The New England journal of medicine,
