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Cellular immunity was assessed in 85 patients with head and neck cancer with monoclonal antibodies to lymphocyte surface antigens that identify total T cells, helper cells, and suppressor cells. The control group consisted of 22 healthy volunteers. Nine patients who had surgical procedures for benign diseases were also studied. Compared with the controls, the patients with cancer who received radiation therapy had a significant decrease in total lymphocytes, T cells, helper cells, suppressor cells, and decreased helper/suppressor cell ratio. Significant decreases in lymphocyte subpopulations were not detected in patients tested before treatment or in patients treated with surgery alone. The immune deficits observed were prolonged in duration, with some present in the patients studied up to 11 years after radiation therapy. This long-lasting immune depression may have relevance to tumor recurrences and second primaries in patients with head and neck cancer treated by radiation therapy and to attempts at increasing cure rates with adjuvant agents that improve immune reactivity.
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
November 1987,
Archives of otolaryngology--head & neck surgery,
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
March 1976,
Cancer,
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
October 1982,
European journal of cancer & clinical oncology,
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
July 1993,
Gaoxiong yi xue ke xue za zhi = The Kaohsiung journal of medical sciences,
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
November 1985,
Archives of otolaryngology (Chicago, Ill. : 1960),
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
January 1991,
Voprosy onkologii,
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
February 2010,
European journal of oncology nursing : the official journal of European Oncology Nursing Society,
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
January 1975,
Surgical forum,
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
November 1984,
Archives of otolaryngology (Chicago, Ill. : 1960),
W C Gray, and
P B Chretien, and
C M Suter, and
D R Revie, and
V T Tomazic, and
C L Blanchard, and
C Aygun, and
R Amornmarn, and
J V Ordonez
January 1997,
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery,
