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The endocrine effects of 125 mg (low dose) aminoglutethimide (AG) twice daily (b.d.) were compared with those of 125 mg AG + 20 mg hydrocortisone (HC) b.d. in 23 and 45 postmenopausal patients with advanced breast cancer, respectively. The patients in each group were drawn from two separate populations, but the mean age and weight of the groups were similar and there were no significant differences between the pretreatment serum levels of the hormones investigated. Serum oestrone and oestradiol levels were suppressed by both treatments, but there was a significantly greater suppression by AG + HC. This greater suppression is probably due to the observed increase in serum androstenedione (i.e. precursor) levels with AG alone, whilst with AG + HC these levels were found to be reduced. In terms of suppression of serum oestrogen levels it is of benefit to combine low dose AG with HC.
M Dowsett, and
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R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
February 1989,
European journal of cancer & clinical oncology,
M Dowsett, and
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R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
September 1987,
European journal of cancer & clinical oncology,
M Dowsett, and
A L Harris, and
R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
October 1986,
Cancer treatment reports,
M Dowsett, and
A L Harris, and
R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
January 1986,
Breast cancer research and treatment,
M Dowsett, and
A L Harris, and
R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
January 1985,
European journal of cancer & clinical oncology,
M Dowsett, and
A L Harris, and
R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
December 1990,
The Journal of steroid biochemistry and molecular biology,
M Dowsett, and
A L Harris, and
R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
July 1989,
European journal of cancer & clinical oncology,
M Dowsett, and
A L Harris, and
R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
January 1986,
Breast cancer research and treatment,
M Dowsett, and
A L Harris, and
R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
June 1994,
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M Dowsett, and
A L Harris, and
R Stuart-Harris, and
M Hill, and
B M Cantwell, and
I E Smith, and
S L Jeffcoate
July 1985,
British journal of cancer,
