BIOMAT Database Logo BIOMAT Database Logo

A new lindenane-type sesquiterpenoid lactone from Chloranthus japonicus. 2019

Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
a School of Biological Science and Technology , University of Jinan , Jinan 250022 , China.

Chromatographic fractionation of the EtOH extracts of the Traditional Chinese Medicine (TCM) Chloranthus japonicus, has led to the isolation of a new lindenane-type sesquiterpenoid lactone derivative (1). Rosmarylchloranthalactone E (1), which consists of lindenane sesquiterpenoid lactone and rosmarinic acid moieties linked via an ester bridge, was structurally elucidated by 1D and 2D NMR and HRMS data. Compound 1 was a potent phosphodiesterase-4 (PDE4) inhibitor with an IC50 value of 0.96 ± 0.04 μM.

UI MeSH Term Description Entries
D007783 Lactones Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES. Lactone
D009682 Magnetic Resonance Spectroscopy Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING). In Vivo NMR Spectroscopy,MR Spectroscopy,Magnetic Resonance,NMR Spectroscopy,NMR Spectroscopy, In Vivo,Nuclear Magnetic Resonance,Spectroscopy, Magnetic Resonance,Spectroscopy, NMR,Spectroscopy, Nuclear Magnetic Resonance,Magnetic Resonance Spectroscopies,Magnetic Resonance, Nuclear,NMR Spectroscopies,Resonance Spectroscopy, Magnetic,Resonance, Magnetic,Resonance, Nuclear Magnetic,Spectroscopies, NMR,Spectroscopy, MR
D012717 Sesquiterpenes Fifteen-carbon compounds formed from three isoprenoid units with general formula C15H24. Farnesanes,Farnesene,Farnesenes,Sesquiterpene,Sesquiterpene Derivatives,Sesquiterpenoid,Sesquiterpenoids,Derivatives, Sesquiterpene
D058988 Phosphodiesterase 4 Inhibitors Compounds that specifically inhibit PHOSPHODIESTERASE 4. PDE-4 Inhibitor,PDE4 Inhibitor,Phosphodiesterase 4 Inhibitor,Phosphodiesterase Type 4 Inhibitor,PDE-4 Inhibitors,PDE4 Inhibitors,Phosphodiesterase Type 4 Inhibitors,4 Inhibitor, Phosphodiesterase,Inhibitor, PDE-4,Inhibitor, PDE4,Inhibitor, Phosphodiesterase 4,Inhibitors, PDE-4,Inhibitors, PDE4,Inhibitors, Phosphodiesterase 4,PDE 4 Inhibitor,PDE 4 Inhibitors
D019684 Magnoliopsida A class of vascular plants which produce flowers and seeds. They include monocotyledons, dicotyledons, and about 80% of all known plant species. Angiosperms,Angiosperma,Angiospermae,Arecidae,Asteridae,Caryophyllidae,Commelinidae,Dicotyledoneae,Dilleniidae,Flowering Plants,Hamamelidae,Hamamelididae,Icacinales,Liliatae,Liliidae,Liliopsida,Magnoliatae,Metteniusales,Oncothecales,Rosidae,Vahliales,Zingiberidae,Angiosperm,Flowering Plant,Icacinale,Metteniusale,Oncothecale,Plant, Flowering,Plants, Flowering,Vahliale

Related Publications

Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
A new eudesmane sesquiterpenoid lactone from Chloranthus japonicus.
January 2012, Chinese journal of natural medicines,
Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
Lindenane sesquiterpenoid dimers from Chloranthus japonicus inhibit HIV-1 and HCV replication.
December 2016, Fitoterapia,
Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
Chloramultiols A-F, lindenane-type sesquiterpenoid dimers from Chloranthus multistachys.
May 2010, Journal of natural products,
Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
Lindenane sesquiterpenoid dimers from Chloranthus japonicus improve LDL uptake by regulating PCSK9 and LDLR.
January 2024, Bioorganic chemistry,
Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
Chlorahololide D, a Lindenane-Type Sesquiterpenoid Dimer from Chloranthus holostegius Suppressing Breast Cancer Progression.
October 2023, Molecules (Basel, Switzerland),
Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
Spicachlorantins G-J, new lindenane sesquiterpenoid dimers from the roots of Chloranthus spicatus.
January 2011, Chemical & pharmaceutical bulletin,
Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
Fortunilides M-O, anti-inflammatory lindenane sesquiterpenoid dimers from Chloranthus fortunei.
July 2023, Fitoterapia,
Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
Lindenane disesquiterpenoids with anti-HIV-1 activity from Chloranthus japonicus.
June 2011, Journal of natural products,
Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
Rearranged Lindenane Sesquiterpenoid Trimers from Chloranthus fortunei: Target Discovery and Biomimetic Conversion.
January 2023, The Journal of organic chemistry,
Cheng-Shi Jiang, and Yan-Qiong Guo, and Sheng Yin, and Hua Zhang, and Gui-Hua Tang
Anti-inflammatory lindenane sesquiterpenoid dimers from the roots of Chloranthus holostegius var. trichoneurus.
May 2024, Journal of natural medicines,
Copied contents to your clipboard!