BIOMAT Database Logo BIOMAT Database Logo

Effect of Ultrasound-Enhanced Transdermal Drug Delivery Efficiency of Nanoparticles and Brucine. 2017

Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.

Brucine is the active component in traditional Chinese medicine "Ma-Qian-Zi" (Strychnos nux-vomica Linn), with capabilities of analgesic, anti-inflammatory, anti-tumor and so on. It is crucial how to break through the impact of cuticle skin which reduces the penetration of drugs to improve drug transmission rate. The aim of this study is to improve the local drug concentration by using ultrasound. We used fresh porcine skin to study the effects of ultrasound on the transdermal absorption of brucine under the influence of various acoustic parameters, including frequency, amplitude and irradiation time. The transdermal conditions of yellow-green fluorescent nanoparticles and brucine in skin samples were observed by laser confocal microscopy and ultraviolet spectrophotometry. The results show that under ultrasonic conditions, the permeability of the skin to the fluorescent label and brucine (e.g., the depth and concentration of penetration) is increased compared to its passive diffusion permeability. The best ultrasound penetration can make the penetration depth of more than 110 microns, fluorescent nanoparticles and brucine concentration increased to 2-3 times. This work will provide supportive data on how the brucine is better used for transdermal drug delivery (TDD).

UI MeSH Term Description Entries
D004337 Drug Carriers Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers. Drug Carrier
D005456 Fluorescent Dyes Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. Flourescent Agent,Fluorescent Dye,Fluorescent Probe,Fluorescent Probes,Fluorochrome,Fluorochromes,Fluorogenic Substrates,Fluorescence Agents,Fluorescent Agents,Fluorogenic Substrate,Agents, Fluorescence,Agents, Fluorescent,Dyes, Fluorescent,Probes, Fluorescent,Substrates, Fluorogenic
D000279 Administration, Cutaneous The application of suitable drug dosage forms to the skin for either local or systemic effects. Cutaneous Drug Administration,Dermal Drug Administration,Drug Administration, Dermal,Percutaneous Administration,Skin Drug Administration,Transcutaneous Administration,Transdermal Administration,Administration, Dermal,Administration, Transcutaneous,Administration, Transdermal,Cutaneous Administration,Cutaneous Administration, Drug,Dermal Administration,Drug Administration, Cutaneous,Skin Administration, Drug,Administration, Cutaneous Drug,Administration, Dermal Drug,Administration, Percutaneous,Administrations, Cutaneous,Administrations, Cutaneous Drug,Administrations, Dermal,Administrations, Dermal Drug,Administrations, Percutaneous,Administrations, Transcutaneous,Administrations, Transdermal,Cutaneous Administrations,Cutaneous Administrations, Drug,Cutaneous Drug Administrations,Dermal Administrations,Dermal Drug Administrations,Drug Administrations, Cutaneous,Drug Administrations, Dermal,Drug Skin Administrations,Percutaneous Administrations,Skin Administrations, Drug,Skin Drug Administrations,Transcutaneous Administrations,Transdermal Administrations
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D000893 Anti-Inflammatory Agents Substances that reduce or suppress INFLAMMATION. Anti-Inflammatory Agent,Antiinflammatory Agent,Agents, Anti-Inflammatory,Agents, Antiinflammatory,Anti-Inflammatories,Antiinflammatories,Antiinflammatory Agents,Agent, Anti-Inflammatory,Agent, Antiinflammatory,Agents, Anti Inflammatory,Anti Inflammatories,Anti Inflammatory Agent,Anti Inflammatory Agents
D012869 Skin Absorption Uptake of substances through the SKIN. Absorption, Skin,Intracutaneous Absorption,Intradermal Absorption,Percutaneous Absorption,Transcutaneous Absorption,Transdermal Absorption,Absorption, Intracutaneous,Absorption, Intradermal,Absorption, Percutaneous,Absorption, Transcutaneous,Absorption, Transdermal,Absorptions, Intracutaneous,Absorptions, Intradermal,Absorptions, Percutaneous,Absorptions, Skin,Absorptions, Transcutaneous,Absorptions, Transdermal,Intracutaneous Absorptions,Intradermal Absorptions,Percutaneous Absorptions,Skin Absorptions,Transcutaneous Absorptions,Transdermal Absorptions
D013331 Strychnine An alkaloid found in the seeds of STRYCHNOS NUX-VOMICA. It is a competitive antagonist at glycine receptors and thus a convulsant. It has been used as an analeptic, in the treatment of nonketotic hyperglycinemia and sleep apnea, and as a rat poison. Strychnine Nitrate,Nitrate, Strychnine
D013552 Swine Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA). Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D014464 Ultrasonic Therapy The use of focused, high-frequency sound waves to produce local hyperthermia in certain diseased or injured parts of the body or to destroy the diseased tissue. Therapeutic Ultrasound,Ultrasound Therapy,Therapy, Ultrasonic,Therapies, Ultrasonic,Therapies, Ultrasound,Therapy, Ultrasound,Ultrasonic Therapies,Ultrasound Therapies,Ultrasound, Therapeutic
D053758 Nanoparticles Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging. Nanocrystalline Materials,Nanocrystals,Material, Nanocrystalline,Materials, Nanocrystalline,Nanocrystal,Nanocrystalline Material,Nanoparticle

Related Publications

Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Effect of nanoparticles on transdermal drug delivery.
January 1991, Journal of microencapsulation,
Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Ultrasound and transdermal drug delivery.
August 2004, Drug discovery today,
Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Ultrasound mediated transdermal drug delivery.
June 2014, Advanced drug delivery reviews,
Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Transducer design for a portable ultrasound enhanced transdermal drug-delivery system.
October 2002, IEEE transactions on ultrasonics, ferroelectrics, and frequency control,
Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Transfersomal Nanoparticles for Enhanced Transdermal Delivery of Clindamycin.
October 2016, AAPS PharmSciTech,
Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Sonophoresis. II. Examination of the mechanism(s) of ultrasound-enhanced transdermal drug delivery.
August 1992, Pharmaceutical research,
Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Effect of ultrasound on transdermal drug delivery to rats and guinea pigs.
June 1989, The Journal of clinical investigation,
Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Perspectives on transdermal ultrasound mediated drug delivery.
January 2007, International journal of nanomedicine,
Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Advances in Ultrasound Mediated Transdermal Drug Delivery.
January 2019, Current pharmaceutical design,
Nongshan Zhang, and Yiyun Wu, and Runlin Xing, and Bo Xu, and Dai Guoliang, and Peimin Wang
Ultrasound-enhanced transdermal delivery: recent advances and future challenges.
July 2014, Therapeutic delivery,
Copied contents to your clipboard!