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The concentrations of beta-endorphin like immunoreactivity (beta-END) in the hypothalamus, pituitary and plasma were studied in rats of either sex, one month after induction of diabetes by single iv injection of streptozotocin. As controls, both normal and undernourished rats, weight-matched with diabetic rats, were used. Diabetic male and female rats had a marked depletion of beta-END stores in the hypothalamus and neurointermediate lobe (NIL) but not in the anterior pituitary. Depletion of beta-END was reversed to normal by insulin replacement therapy. Severe undernourishment was not as effective as diabetes to reduce beta-END stores in the hypothalamus and NIL. A significant reduction of beta-END was observed only in the NIL of undernourished female rats. Plasma beta-END and beta-lipotropin (beta-LPH) concentrations were not significantly altered in diabetic rats. These results indicate that the lack of insulin may affect beta-END synthesis in the hypothalamus and NIL.
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
February 1989,
Clinical and experimental pharmacology & physiology,
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
October 2002,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
January 1981,
Neurobiology of aging,
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
March 1987,
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
January 1990,
Endocrinology,
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
April 2007,
Life sciences,
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
March 2006,
Journal of ethnopharmacology,
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
April 2003,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
September 2004,
Evidence-based complementary and alternative medicine : eCAM,
V Locatelli, and
F Petraglia, and
N Tirloni, and
E E Müller
December 2003,
The Journal of pharmacology and experimental therapeutics,
