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Discovery of a novel potent GPR40 full agonist. 2018
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
CVM Discovery, Janssen Research & Developmen, LLC, Welsh and McKean Roads, Spring House, PA 19477-0776, USA.
Compound 12 is a GPR40 agonist that realizes the full magnitude of efficacy possible via GPR40 receptor agonism. In vitro and in vivo studies demonstrated superior glucose lowering by 12 compared to fasiglifam (TAK-875), in a glucose dependent manner. The enhanced efficacy observed with the full agonist 12 was associated with both direct and indirect stimulation of insulin secretion.
Related Publications
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
September 2012,
ACS medicinal chemistry letters,
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Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
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Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
March 2015,
ACS medicinal chemistry letters,
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
July 2018,
ACS medicinal chemistry letters,
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
September 2010,
ACS medicinal chemistry letters,
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
June 2013,
ACS medicinal chemistry letters,
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
November 2019,
Bioorganic chemistry,
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
January 2012,
Bioorganic & medicinal chemistry letters,
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
March 2004,
Journal of medicinal chemistry,
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
November 2011,
Bioorganic & medicinal chemistry letters,
Sanath K Meegalla, and
Hui Huang, and
Tonya Martin, and
June Xu, and
Shuyuan Zhao, and
Jianying Liu, and
Meghan Hall, and
Joe Gunnet, and
Yuanping Wang, and
Brian Rady, and
Jose Silva, and
Monicah Otieno, and
Eric Arnoult, and
S Paul Lee, and
Alessandro Pocai, and
Mark R Player
April 2017,
Journal of medicinal chemistry,
