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A new limonoid from stem bark of Chisocheton pentandrus (Meliaceae). 2018
Supriatno, and
Nurlelasari, and
Tati Herlina, and
Desi Harneti, and
Rani Maharani, and
Ace Tatang Hidayat, and
Tri Mayanti, and
Unang Supratman, and
Mohamad Nurul Azmi, and
Yoshihito Shiono
a Faculty of Mathematics and Natural Sciences, Department of Chemistry , Universitas Padjadjaran , Jatinangor , Indonesia.
A new limonoid, pentandricine (1), along with three known limonoids, ceramicine B (2), 6-de(acetyloxy)-23-oxochisocheton (3), 6-de(acetyloxy)-23-oxo-7-O-deacetylchisocheton (4), have been isolated from the stembark of Chisocheton pentandrus. The chemical structures of the new compound were elucidated on the basis of spectroscopic evidence. All of the compounds were tested for their cytotoxic effects against MCF-7 breast cancer cells. Compounds 1-4 showed weak and no cytotoxicity against MCF-7 breast cancer cells with IC50 values of 369.84, 150.86, 208.93 and 120.09 μM, respectively.
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