SOX2 activation predicts prognosis in patients with head and neck squamous cell carcinoma. 2018

Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Kyung Hee University, Seoul, South Korea.

SOX2 copy number and mRNA expression were analysed to examine the clinical significance of SOX2 activation in HNSCC. Gene expression signatures reflecting SOX2 activation were identified in an HNSCC cohort. Patients with HNSCC were classified into two subgroups according to the gene expression signature: SOX2-high and SOX2-low. The clinical significance of SOX2 activation was further validated in two independent cohorts. Moreover, clinical significance of SOX2 activation in response to radiotherapy was assessed in patients with HNSCC. The relationship between SOX2 activation and radiotherapy was validated in an in vitro experiment. Patients in the SOX2-high subgroup had a better prognosis than patients in the SOX2-low subgroup in all three patient cohorts. Results of multivariate regression analysis showed that SOX2 signature was an independent predictor of the overall survival of patients with HNSCC (hazard ratio, 1.45; 95% confidence interval, 1.09-1.92; P = 0.01). Interestingly, SOX2 activation was a predictor of therapy outcomes in patients receiving radiotherapy. Moreover, SOX2 overexpression enhanced the effect of radiotherapy in HNSCC cell lines. SOX2 activation is associated with improved prognosis of patients with HNSCC and might be used to predict which patients might benefit from radiotherapy.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D002294 Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed) Carcinoma, Epidermoid,Carcinoma, Planocellular,Carcinoma, Squamous,Squamous Cell Carcinoma,Carcinomas, Epidermoid,Carcinomas, Planocellular,Carcinomas, Squamous,Carcinomas, Squamous Cell,Epidermoid Carcinoma,Epidermoid Carcinomas,Planocellular Carcinoma,Planocellular Carcinomas,Squamous Carcinoma,Squamous Carcinomas,Squamous Cell Carcinomas
D005260 Female Females
D006258 Head and Neck Neoplasms Soft tissue tumors or cancer arising from the mucosal surfaces of the LIP; oral cavity; PHARYNX; LARYNX; and cervical esophagus. Other sites included are the NOSE and PARANASAL SINUSES; SALIVARY GLANDS; THYROID GLAND and PARATHYROID GLANDS; and MELANOMA and non-melanoma skin cancers of the head and neck. (from Holland et al., Cancer Medicine, 4th ed, p1651) Cancer of Head and Neck,Head Cancer,Head Neoplasm,Head and Neck Cancer,Head and Neck Neoplasm,Neck Cancer,Neck Neoplasm,Neck Neoplasms,Neoplasms, Upper Aerodigestive Tract,UADT Neoplasm,Upper Aerodigestive Tract Neoplasm,Upper Aerodigestive Tract Neoplasms,Cancer of Head,Cancer of Neck,Cancer of the Head,Cancer of the Head and Neck,Cancer of the Neck,Head Neoplasms,Head, Neck Neoplasms,Neoplasms, Head,Neoplasms, Head and Neck,Neoplasms, Neck,UADT Neoplasms,Cancer, Head,Cancer, Neck,Cancers, Head,Cancers, Neck,Head Cancers,Neck Cancers,Neoplasm, Head,Neoplasm, Neck,Neoplasm, UADT,Neoplasms, UADT
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D012333 RNA, Messenger RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm. Messenger RNA,Messenger RNA, Polyadenylated,Poly(A) Tail,Poly(A)+ RNA,Poly(A)+ mRNA,RNA, Messenger, Polyadenylated,RNA, Polyadenylated,mRNA,mRNA, Non-Polyadenylated,mRNA, Polyadenylated,Non-Polyadenylated mRNA,Poly(A) RNA,Polyadenylated mRNA,Non Polyadenylated mRNA,Polyadenylated Messenger RNA,Polyadenylated RNA,RNA, Polyadenylated Messenger,mRNA, Non Polyadenylated
D016019 Survival Analysis A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function. Analysis, Survival,Analyses, Survival,Survival Analyses

Related Publications

Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
January 2020, Cancer management and research,
Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
January 2018, Journal of Cancer,
Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
January 2024, Nutrition and cancer,
Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
January 2023, Frontiers in oncology,
Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
July 2019, Histology and histopathology,
Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
April 2008, Scandinavian journal of immunology,
Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
January 2021, Journal of Cancer,
Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
June 2023, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer,
Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
October 2016, Anticancer research,
Ji Hyun Chung, and Hae Rim Jung, and Ah Ra Jung, and Young Chan Lee, and Moonkyoo Kong, and Ju-Seog Lee, and Young-Gyu Eun
March 2021, Scientific reports,
Copied contents to your clipboard!