-transparent.png){kind=logo}
Incubation of purified cardiac sarcolemmal vesicles (SL) in the presence of S-adenosyl-L-methionine, a methyl donor for the enzymatic N-methylation of phosphatidylethanolamine (PE), increased the Ca2+-stimulated ATPase and ATP-dependent Ca2+ accumulation activities. Quantitative analysis of the methylated phospholipids revealed that maximal increase of Ca2+-pump activities was associated with predominant synthesis and intramembranal accumulation of phosphatidyl-N,N-dimethylethanolamine. The stimulation of SL Ca2+-pump activities was prevented by inhibitors of PE N-methylation such as S-adenosyl-L-homocysteine and methyl acetimidate hydrochloride. The results suggest a possible role of PE N-methylation in the regulation of Ca2+-transport across the heart SL membrane.
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
November 1997,
Molecular and cellular biochemistry,
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
November 1989,
Journal of cardiovascular pharmacology,
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
August 1987,
European journal of biochemistry,
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
March 1983,
Canadian journal of physiology and pharmacology,
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
September 1986,
Life sciences,
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
July 1990,
Biochemical and biophysical research communications,
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
April 1981,
Biochimica et biophysica acta,
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
November 1987,
Molecular and cellular biochemistry,
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
February 1985,
Biochimica et biophysica acta,
V Panagia, and
K Okumura, and
N Makino, and
N S Dhalla
October 1987,
Molecular and cellular biochemistry,
