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Relay photocatalytic cascade reactions: synthesis of indolo[2,1-a]isoquinoline derivatives via double C(sp3)-H bond functionalization. 2018

Jian Cheng, and Jin Xie, and Chengjian Zhu
State Key Laboratory of Coordination Chemistry, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, 210023, P. R. China. xie@nju.edu.cn cjzhu@nju.edu.cn.

A relay photoredox catalysis strategy concomitant with [1,5] hydrogen atom transfer has been applied in the construction of a biologically important indolo[2,1-a]isoquinoline framework via a cascade reaction. This reaction enables double C(sp3)-H bond functionalization and formation of two carbon-carbon double bonds from readily available starting materials in an efficient and step-economical manner.

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