-transparent.png){kind=logo}
The impact of hepatitis B vaccine on hepatic mixed function oxidase activity was studied using antipyrine as a probe. Fifteen health care workers who elected to take the vaccine due to occupational risk were the subjects. Each subject received all three vaccinations over a period of six months. Antipyrine (500 mg) was administered orally prior to the first vaccination, 1 week subsequent to each vaccination, and one month after the final vaccination, and antipyrine clearance, CL/F was estimated from concentrations of antipyrine in saliva collected 24 hr after each antipyrine dose. The mean (+/- SD) pre-vaccination CL/F was 3.65 (+/- 0.75) 1/hr. Post vaccination mean CL/F values deviated by no more than 8.8% and none of the post vaccination values were significantly different from the pre-vaccination mean. It is inappropriate to extrapolate findings concerning one antiviral vaccine and its putative effect on drug metabolism to other antiviral vaccines.
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
April 1994,
British journal of clinical pharmacology,
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
February 1997,
Hepatology (Baltimore, Md.),
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
July 1981,
Clinical pharmacology and therapeutics,
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
January 1995,
Journal of hepatology,
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
October 1986,
Clinical pharmacology and therapeutics,
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
May 1980,
Revista espanola de las enfermedades del aparato digestivo,
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
June 1985,
Clinical pharmacology and therapeutics,
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
January 1981,
British medical journal (Clinical research ed.),
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
September 1981,
Revista medica de Chile,
K Bachmann, and
J Schwartz, and
L Jauregui, and
R Forney
September 1982,
Annals of internal medicine,
