Biomaterial Database

Muscle fiber type changes in human skeletal muscle after injuries and immobilization. 1986

T Häggmark, and E Eriksson, and E Jansson

Eight athletes operated on for knee injuries were followed with muscle biopsies before and at various intervals after surgery and immobilization. A statistically significant change of the muscle fiber distribution was found. The percentage type I fibers dropped from an average of 54% to 43%. One competitive cross-country skier showed a dramatic drop from 81% type I fibers at surgery to 58% type I fibers six weeks later. After beginning training he returned to 85% type I fibers. One athlete who had been operated and immobilized for long periods several times showed a drastic difference in fiber type distribution between his two thighs with 20% type I fibers in the injured leg and 69% type I fibers in his uninjured leg. After three years of training his fiber type composition in the injured leg returned toward the fiber type distribution of the uninjured thigh. It is evident that muscle fiber type composition can change. The most probable reason for this is that the drastic change from hard sports training to nearly complete immobilization influences both the muscle itself and its innervation and causes this change of fiber types.

UI	MeSH Term	Description	Entries
D007103	Immobilization	The restriction of the MOVEMENT of whole or part of the body by physical means (RESTRAINT, PHYSICAL) or chemically by ANALGESIA, or the use of TRANQUILIZING AGENTS or NEUROMUSCULAR NONDEPOLARIZING AGENTS. It includes experimental protocols used to evaluate the physiologic effects of immobility.	Hypokinesia, Experimental,Experimental Hypokinesia,Experimental Hypokinesias,Hypokinesias, Experimental
D007718	Knee Injuries	Injuries to the knee or the knee joint.	Injuries, Knee,Injury, Knee,Knee Injury
D008297	Male		Males
D009132	Muscles	Contractile tissue that produces movement in animals.	Muscle Tissue,Muscle,Muscle Tissues,Tissue, Muscle,Tissues, Muscle
D009210	Myofibrils	The long cylindrical contractile organelles of STRIATED MUSCLE cells composed of ACTIN FILAMENTS; MYOSIN filaments; and other proteins organized in arrays of repeating units called SARCOMERES .	Myofilaments,Myofibril,Myofilament
D011184	Postoperative Period	The period following a surgical operation.	Period, Postoperative,Periods, Postoperative,Postoperative Periods
D002370	Casts, Surgical	Dressings made of fiberglass, plastic, or bandage impregnated with plaster of paris used for immobilization of various parts of the body in cases of fractures, dislocations, and infected wounds. In comparison with plaster casts, casts made of fiberglass or plastic are lightweight, radiolucent, able to withstand moisture, and less rigid.	Fiberglass Casts,Plaster Casts,Plastic Casts,Cast, Surgical,Surgical Cast,Surgical Casts,Cast, Fiberglass,Cast, Plaster,Cast, Plastic,Casts, Fiberglass,Casts, Plaster,Casts, Plastic,Fiberglass Cast,Plaster Cast,Plastic Cast
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000251	Adenosine Triphosphatases	A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.	ATPases,Adenosinetriphosphatase,ATPase,ATPase, DNA-Dependent,Adenosine Triphosphatase,DNA-Dependent ATPase,DNA-Dependent Adenosinetriphosphatases,ATPase, DNA Dependent,Adenosinetriphosphatases, DNA-Dependent,DNA Dependent ATPase,DNA Dependent Adenosinetriphosphatases,Triphosphatase, Adenosine
D001706	Biopsy	Removal and pathologic examination of specimens from the living body.	Biopsies