[Noninvasive diagnosis of pulmonary arterial hypertension in chronic respiratory insufficiency]. 1985

E Weitzenblum, and M Mammosser, and T Oswald, and E Roegel

A precise assessment of pulmonary arterial hypertension (HTAP) in chronic lung disorders is not possible without right heart catheterisation. In spite of technological advances (floating catheters with or without balloons) the examination remains invasive, at least to a certain degree, in addition it is not currently practiced in respiratory function laboratories or in services specialising in thoracic medicine. The diagnosis of HTAP is important when considering both the prognosis and the therapeutic approach notably in chronic airflow obstruction (BPCO) and thus the interest in non-invasive diagnostic methods for HTAP. Do current methods offer such a diagnosis? It is this question that the authors endeavour to answer in analysing the possibilities of the principle methods available, from the most standard (eg ECG, chest radiographs) to the most recent (right heart echo-cardiography, myocardial scintigraphy, isotopic measurement of the right heart function). The reference factor is usually the mean pulmonary artery pressure at rest (PAP) supplied by right heart catheterisation. The ideas of sensibility and specificity of a method are defined and the importance of the correlation between the numerical results obtained by a given method and right heart catheterisation is emphasized: only a very strong correlation could assure the possibility of a correct prediction of the level of PAP. Individually no current methods allow such a prediction in a satisfactory manner. Right heart echo-cardiography is "a priori" the most tempting, but it is unfortunately difficult to accomplish in patients with BPCO. Bidimensional echo-cardiography and the Doppler have given very promising results, which need to be confirmed in patients with BPCO. By combining the results of several methods (eg. ECG, radiological measurements, echocardiography) to those of respiratory function (FEV1, PaO2, PaCO2) one can predict in a satisfactory manner the existence (or the absence) of HTAP but not the precise level of the PAP. An approach of this kind may help to limit the indications for right heart catheterisation which remains irreplaceable for the precise knowledge of pulmonary hemodynamic parameters.

UI MeSH Term Description Entries
D006976 Hypertension, Pulmonary Increased VASCULAR RESISTANCE in the PULMONARY CIRCULATION, usually secondary to HEART DISEASES or LUNG DISEASES. Pulmonary Hypertension
D007702 Kinetocardiography The graphic recording of chest wall movement due to cardiac impulses. Accelography,Apex Cardiography,Vibrocardiography,Cardiography, Apex,Accelographies,Apex Cardiographies,Cardiographies, Apex,Kinetocardiographies,Vibrocardiographies
D011651 Pulmonary Artery The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs. Arteries, Pulmonary,Artery, Pulmonary,Pulmonary Arteries
D011664 Pulmonary Valve A valve situated at the entrance to the pulmonary trunk from the right ventricle. Pulmonary Valves,Valve, Pulmonary,Valves, Pulmonary
D011868 Radioisotopes Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) Daughter Isotope,Daughter Nuclide,Radioactive Isotope,Radioactive Isotopes,Radiogenic Isotope,Radioisotope,Radionuclide,Radionuclides,Daughter Nuclides,Daugter Isotopes,Radiogenic Isotopes,Isotope, Daughter,Isotope, Radioactive,Isotope, Radiogenic,Isotopes, Daugter,Isotopes, Radioactive,Isotopes, Radiogenic,Nuclide, Daughter,Nuclides, Daughter
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D012129 Respiratory Function Tests Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc. Lung Function Tests,Pulmonary Function Tests,Function Test, Pulmonary,Function Tests, Pulmonary,Pulmonary Function Test,Test, Pulmonary Function,Tests, Pulmonary Function,Function Test, Lung,Function Test, Respiratory,Function Tests, Lung,Function Tests, Respiratory,Lung Function Test,Respiratory Function Test,Test, Lung Function,Test, Respiratory Function,Tests, Lung Function,Tests, Respiratory Function
D012131 Respiratory Insufficiency Failure to adequately provide oxygen to cells of the body and to remove excess carbon dioxide from them. (Stedman, 25th ed) Acute Hypercapnic Respiratory Failure,Acute Hypoxemic Respiratory Failure,Hypercapnic Acute Respiratory Failure,Hypercapnic Respiratory Failure,Hypoxemic Acute Respiratory Failure,Hypoxemic Respiratory Failure,Respiratory Depression,Respiratory Failure,Ventilatory Depression,Depressions, Ventilatory,Failure, Hypercapnic Respiratory,Failure, Hypoxemic Respiratory,Failure, Respiratory,Hypercapnic Respiratory Failures,Hypoxemic Respiratory Failures,Respiratory Failure, Hypercapnic,Respiratory Failure, Hypoxemic,Respiratory Failures
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002908 Chronic Disease Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care (Dictionary of Health Services Management, 2d ed). For epidemiological studies chronic disease often includes HEART DISEASES; STROKE; CANCER; and diabetes (DIABETES MELLITUS, TYPE 2). Chronic Condition,Chronic Illness,Chronically Ill,Chronic Conditions,Chronic Diseases,Chronic Illnesses,Condition, Chronic,Disease, Chronic,Illness, Chronic

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