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Anosognosia in mild Alzheimer's disease is correlated with not only neural dysfunction but also compensation. 2018

Kenji Tagai, and Shunichiro Shinagawa, and Hidehiro Kada, and Keisuke Inamura, and Tomoyuki Nagata, and Kazuhiko Nakayama
Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan.

BACKGROUND Anosognosia in Alzheimer's disease (AD) is a complicated, non-unitary phenomenon. In a clinical setting, patients with mild AD often preserve their awareness partially. We hypothesized that compensation, as well as neural dysfunction, could be correlated with anosognosia in mild AD. METHODS The severity of anosognosia was evaluated using the Anosognosia Questionnaire for Dementia in 37 subjects with mild AD or mild cognitive impairment due to AD. The subjects also underwent single-photon emission computed tomography with N-isopropyl-p-[123 I]iodoamphetamine. Correlation between the severity of anosognosia and perfusion was assessed, and anosognosia (+) and (-) groups were compared. RESULTS The severity of anosognosia was relatively mild; the mean Anosognosia Questionnaire for Dementia score was 6.76 ± 14.16. Subjects were divided into two groups: anosognosia (+) (n = 11) and anosognosia (-) (n = 26). In the single-photon emission computed tomography data analysis, the severity of anosognosia was correlated with both lower regional cerebral blood flows of the right prefrontal cortex and higher regional cerebral blood flows of the parietal cortex, especially the left temporo-parietal junction. CONCLUSIONS Our results suggest that anosognosia in mild AD could be correlated with compensation as well as neural dysfunction. We speculate that this compensation may be related to the retrieval of outdated autobiographical memory.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009483 Neuropsychological Tests Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury. Aphasia Tests,Cognitive Test,Cognitive Testing,Cognitive Tests,Memory for Designs Test,Neuropsychological Testing,AX-CPT,Behavioral Assessment of Dysexecutive Syndrome,CANTAB,Cambridge Neuropsychological Test Automated Battery,Clock Test,Cognitive Function Scanner,Continuous Performance Task,Controlled Oral Word Association Test,Delis-Kaplan Executive Function System,Developmental Neuropsychological Assessment,Hooper Visual Organization Test,NEPSY,Neuropsychologic Tests,Neuropsychological Test,Paced Auditory Serial Addition Test,Repeatable Battery for the Assessment of Neuropsychological Status,Rey-Osterrieth Complex Figure,Symbol Digit Modalities Test,Test of Everyday Attention,Test, Neuropsychological,Tests, Neuropsychological,Tower of London Test,Neuropsychologic Test,Test, Cognitive,Testing, Cognitive,Testing, Neuropsychological,Tests, Cognitive
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D002560 Cerebrovascular Circulation The circulation of blood through the BLOOD VESSELS of the BRAIN. Brain Blood Flow,Regional Cerebral Blood Flow,Cerebral Blood Flow,Cerebral Circulation,Cerebral Perfusion Pressure,Circulation, Cerebrovascular,Blood Flow, Brain,Blood Flow, Cerebral,Brain Blood Flows,Cerebral Blood Flows,Cerebral Circulations,Cerebral Perfusion Pressures,Circulation, Cerebral,Flow, Brain Blood,Flow, Cerebral Blood,Perfusion Pressure, Cerebral,Pressure, Cerebral Perfusion
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000369 Aged, 80 and over Persons 80 years of age and older. Oldest Old
D000377 Agnosia Loss of the ability to comprehend the meaning or recognize the importance of various forms of stimulation that cannot be attributed to impairment of a primary sensory modality. Tactile agnosia is characterized by an inability to perceive the shape and nature of an object by touch alone, despite unimpaired sensation to light touch, position, and other primary sensory modalities. Auditory Agnosia,Finger Agnosia,Sensory Agnosia,Tactile Agnosia,Visual Agnosia,Agnosia for Pain,Agnosia for Smell,Agnosia for Taste,Agnosia for Temperature,Anosognosia,Auditory Agnosia, Congenital,Body-Image Agnosia,Congenital Auditory Agnosia,Developmental Agnosia,Gustatory Agnosia,Ideational Agnosia,Olfactory Agnosia,Position Agnosia,Somatosensory Agnosia,Time Agnosia,Topographical Agnosia,Visual Agnosia for Objects,Visual Disorientation Syndrome,Visuospatial Agnosia,Agnosia for Tastes,Agnosia, Auditory,Agnosia, Body-Image,Agnosia, Congenital Auditory,Agnosia, Developmental,Agnosia, Finger,Agnosia, Gustatory,Agnosia, Ideational,Agnosia, Olfactory,Agnosia, Position,Agnosia, Sensory,Agnosia, Somatosensory,Agnosia, Tactile,Agnosia, Time,Agnosia, Topographical,Agnosia, Visual,Agnosia, Visuospatial,Agnosias,Agnosias, Auditory,Agnosias, Body-Image,Agnosias, Congenital Auditory,Agnosias, Developmental,Agnosias, Finger,Agnosias, Ideational,Agnosias, Olfactory,Agnosias, Position,Agnosias, Sensory,Agnosias, Somatosensory,Agnosias, Tactile,Agnosias, Time,Agnosias, Topographical,Agnosias, Visual,Agnosias, Visuospatial,Anosognosias,Auditory Agnosias,Auditory Agnosias, Congenital,Body Image Agnosia,Body-Image Agnosias,Congenital Auditory Agnosias,Developmental Agnosias,Finger Agnosias,Ideational Agnosias,Olfactory Agnosias,Position Agnosias,Sensory Agnosias,Somatosensory Agnosias,Syndrome, Visual Disorientation,Syndromes, Visual Disorientation,Tactile Agnosias,Time Agnosias,Topographical Agnosias,Visual Agnosias,Visual Disorientation Syndromes,Visuospatial Agnosias

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