-transparent.png){kind=logo}
Cultured thymic fragments were implanted in one patient with acquired immunodeficiency syndrome (AIDS)-related complex (ARC) and in eight AIDS patients with opportunistic infections (OIs, four patients), Kaposi's sarcoma (KS, two patients), or both (two patients). Thereafter, objective clinical improvement was noted in one patient with OI, and a stable symptom-free condition was observed in the ARC patient and in two other patients with OIs. However, the ARC patient and two of the three patients with OIs developed infections three to six months after implantation. A fourth case of OI and the patients with KS showed progression of the disease. Peripheral blood investigations for counts of total leukocytes, lymphocytes, and T-lymphocyte subsets as well as for lymphocyte stimulation with mitogens showed no changes interpretable as an improvement of the cellular immune deficiency status. We conclude that cultured thymic fragments have no distinct in vivo effect on the course of AIDS, except for a temporary clinical improvement or a period of stable condition in some patients with OIs.
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
June 1986,
Archives of internal medicine,
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
April 1983,
The New England journal of medicine,
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
July 1983,
The New England journal of medicine,
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
January 1996,
The Pediatric infectious disease journal,
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
December 1984,
Israel journal of medical sciences,
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
October 1986,
Journal of immunology (Baltimore, Md. : 1950),
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
May 1991,
Clinical pharmacology and therapeutics,
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
October 1989,
The Journal of thoracic and cardiovascular surgery,
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
May 1997,
Journal of the American College of Surgeons,
S A Danner, and
H J Schuurman, and
J M Lange, and
F H Gmelig Meyling, and
P T Schellekens, and
J Huber, and
L Kater
May 1992,
Archives of internal medicine,
