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Insulin and glucagon secretion was investigated in ten patients with hepatic glycogenosis, types I and III, in order to understand the relationship between hypoglycemia and pancreatic function. In all patients, both oral glucose tolerance and intravenous arginine infusion tests revealed hypoinsulinemia. Decreased urinary C-peptide levels with standard food intake also supported hypofunction of pancreatic beta cells. On the contrary, the normal secretion pattern of glucagon in both types indicated in the arginine loading test, intact alpha cells in the pancreas. Persistent hypoinsulinism, which is apparently an adaptation to hypoglycemia, could be an important cause of nutritional dwarfism in both types of glycogenosis. The usefulness of the measurement of urinary C-peptide, which evaluates the pancreatic function and provides management for normal body growth, is discussed.
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H Kodama, and
T Yutaka, and
K Inui, and
M Ishida, and
H Yabuuchi, and
Y Seino
April 2014,
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S Okada, and
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M Ishida, and
H Yabuuchi, and
Y Seino
July 1978,
The American journal of physiology,
S Okada, and
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M Ishida, and
H Yabuuchi, and
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November 1965,
Lancet (London, England),
S Okada, and
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H Kodama, and
T Yutaka, and
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Y Seino
December 1986,
Neuroscience letters,
S Okada, and
Y Seino, and
H Kodama, and
T Yutaka, and
K Inui, and
M Ishida, and
H Yabuuchi, and
Y Seino
June 1971,
Lancet (London, England),
S Okada, and
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H Kodama, and
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H Yabuuchi, and
Y Seino
January 1988,
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S Okada, and
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H Kodama, and
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Y Seino
October 1971,
Lancet (London, England),
S Okada, and
Y Seino, and
H Kodama, and
T Yutaka, and
K Inui, and
M Ishida, and
H Yabuuchi, and
Y Seino
April 1967,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
S Okada, and
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H Yabuuchi, and
Y Seino
October 1971,
Ugeskrift for laeger,
S Okada, and
Y Seino, and
H Kodama, and
T Yutaka, and
K Inui, and
M Ishida, and
H Yabuuchi, and
Y Seino
June 1981,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
