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The antiatherosclerotic profile of nicotinic acid and of its new water-insoluble derivative was studied in an 8-day experiment in rats. Both drugs lowered plasma triglyceride levels significantly, while other lipoprotein parameters were unaffected. Circulating immune complex levels were decreased with lysosomal membrane permeability by both drugs. Glunicate proved to be a powerful antioxidant with regard to enzymatic lipid peroxidation when studied in the liver microsomal system. The relevance of these findings to the antiatherosclerotic effect of the drugs and the biological significance of antioxidant treatment is discussed. On the basis of these data glunicate seems to be a promising new therapeutic tool against atherosclerosis and merits further study.
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
November 1984,
Kardiologiia,
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
January 1991,
Roczniki Panstwowego Zakladu Higieny,
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
December 1983,
The Indian journal of medical research,
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
January 1975,
Eksperimentalna meditsina i morfologiia,
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
January 2014,
International journal of clinical and experimental pathology,
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
January 1980,
Die Nahrung,
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
June 1975,
Comptes rendus hebdomadaires des seances de l'Academie des sciences. Serie D: Sciences naturelles,
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
May 1993,
Indian journal of experimental biology,
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
October 1978,
Indian journal of biochemistry & biophysics,
J Fehér, and
A Kiss, and
A Blazovics, and
E Szondy, and
H Toncsev, and
D Mathiász, and
S Gerö
November 1999,
Wei sheng yan jiu = Journal of hygiene research,
