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The pure and selective serotonin blocking agent ketanserin (5-HT2 receptor blocker) was used to evaluate a possible role for serotonin as a mediator of the pulmonary vasoconstrictor response to alveolar hypoxia. Isolated and ventilated lungs (FiO2 = 0.21) from rats were perfused at 310 degrees (K) with homologous blood at constant volume inflow, and pressor responses to standardized periods of ventilation hypoxia (FIO2 = 0.02) were recorded. Pressor responses to pulmonary arterial bolus-injections of serotonin were tested both before and after administration of ketanserin for comparison with the responses to hypoxia. We found that ketanserin in doses adequate to block the response to serotonin, had no effect on the pulmonary vasoconstrictor response to hypoxia.
K G Helgesen, and
L Bjertnaes
October 1989,
Journal of cardiothoracic anesthesia,
K G Helgesen, and
L Bjertnaes
April 1989,
Pediatric research,
K G Helgesen, and
L Bjertnaes
January 1977,
Acta anaesthesiologica Scandinavica,
K G Helgesen, and
L Bjertnaes
July 1988,
Nihon Kyobu Shikkan Gakkai zasshi,
K G Helgesen, and
L Bjertnaes
September 1985,
European journal of anaesthesiology,
K G Helgesen, and
L Bjertnaes
March 1968,
Acta physiologica Scandinavica,
K G Helgesen, and
L Bjertnaes
July 1985,
Microvascular research,
K G Helgesen, and
L Bjertnaes
November 1994,
British journal of pharmacology,
K G Helgesen, and
L Bjertnaes
March 2000,
Anesthesia and analgesia,
K G Helgesen, and
L Bjertnaes
January 1991,
Journal of applied physiology (Bethesda, Md. : 1985),
