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The rate of disappearance of radioiodinated forms of 3 different atrial natriuretic factors (ANF (Ser 99-Tyr 126), ANF (Arg 101-Tyr 126), ANF (Ser 103-Tyr 126)) from circulation in the rat was studied. Before proceeding to study the half-life of these peptides, the biological activity of their cold iodinated forms was examined. Upon incorporation of iodine into the ANF molecule, there was a 2 to 5-fold loss in their binding affinities to mesenteric arteries and adrenal capsules as compared to their respective uniodinated forms. A similar loss in their potency to inhibit basal aldosterone release from adrenal zona glomerulosa cells was observed. The rate of disappearance of the radioiodinated peptides from plasma was very fast; the half-life of ANF (Ser 99-Tyr 126) was 16.8 +/- 0.9 sec. Similar values were also obtained for ANF (Arg 101-Tyr 126) and ANF (Ser 103-Tyr 126). The in vivo disappearance of ANF from plasma is probably due to the binding to receptors in the cells since in vitro incubation of ANF (Ser 99-Tyr 126) with rat plasma caused only a slight loss in its immunoreactivity in the first 5 minutes. Hepatectomy and nephrectomy did not cause any major prolongation of the disappearance rate suggesting that these two organs may not be the primary sites involved in the removal of this peptide from circulation.
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
February 1996,
The Journal of physiology,
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
April 1985,
The Journal of biological chemistry,
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
April 1986,
Biochemical and biophysical research communications,
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
July 1986,
Journal of the American College of Cardiology,
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
April 1986,
European journal of pharmacology,
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
August 1984,
L'union medicale du Canada,
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
January 1985,
Clinical and experimental hypertension. Part A, Theory and practice,
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
April 1986,
The American journal of physiology,
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
August 1991,
The Journal of endocrinology,
K K Murthy, and
G Thibault, and
E L Schiffrin, and
R Garcia, and
L Chartier, and
J Gutkowska, and
J Genest, and
M Cantin
December 1985,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
