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The effect of treatment with intravenously administered Angiotensin II (AT II) on blood flow in normal and malignant tissues was investigated clinically. The time course of the effect of AT II was directly recorded by laser doppler velocimetry (LDV) via a probe placed on the surface of normal and malignant tissues. Intravenous administration of AT II resulted in an approximate 3.5 (1.3-14.0)-fold increase in blood flow in eleven malignant tissues, such as breast cancer with direct extension to the skin and abdominal skin metastasis of gastric adenocarcinoma. On the other hand, the blood flow in normal skin was decreased under AT II-induced hypertension, but a reactive hyperemia-like increase was observed soon after the withdrawal of AT II. These results strongly suggested that intravenously administered AT II can act as an adjuvant to enhance, by varying degrees, drug delivery to tumor tissue in cancer chemotherapy and that the administration of chemotherapeutic agents is undesirable soon after the withdrawal of AT II.
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
June 1982,
The American journal of physiology,
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
January 1984,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
May 1984,
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology,
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
May 1987,
Diseases of the colon and rectum,
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
December 1990,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
July 1991,
International journal of dermatology,
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
April 1977,
The American journal of physiology,
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
July 1982,
Microvascular research,
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
March 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
T Kudo, and
S Abo, and
T Itabashi, and
K Watanabe, and
K Onodera, and
N Shimoma, and
Y Kawamura, and
M Hashimoto, and
T Kato, and
K Watanabe
October 1982,
Life sciences,
