Bidirectional and long-lasting control of alcohol-seeking behavior by corticostriatal LTP and LTD. 2018

Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M University Health Science Center, Bryan, TX, USA.

Addiction is proposed to arise from alterations in synaptic strength via mechanisms of long-term potentiation (LTP) and depression (LTD). However, the causality between these synaptic processes and addictive behaviors is difficult to demonstrate. Here we report that LTP and LTD induction altered operant alcohol self-administration, a motivated drug-seeking behavior. We first induced LTP by pairing presynaptic glutamatergic stimulation with optogenetic postsynaptic depolarization in the dorsomedial striatum, a brain region known to control goal-directed behavior. Blockade of this LTP by NMDA-receptor inhibition unmasked an endocannabinoid-dependent LTD. In vivo application of the LTP-inducing protocol caused a long-lasting increase in alcohol-seeking behavior, while the LTD protocol decreased this behavior. We further identified that optogenetic LTP and LTD induction at cortical inputs onto striatal dopamine D1 receptor-expressing neurons controlled these behavioral changes. Our results demonstrate a causal link between synaptic plasticity and alcohol-seeking behavior and suggest that modulation of this plasticity may inspire a therapeutic strategy for addiction.

UI MeSH Term Description Entries
D008297 Male Males
D002540 Cerebral Cortex The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulci. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions. Allocortex,Archipallium,Cortex Cerebri,Cortical Plate,Paleocortex,Periallocortex,Allocortices,Archipalliums,Cerebral Cortices,Cortex Cerebrus,Cortex, Cerebral,Cortical Plates,Paleocortices,Periallocortices,Plate, Cortical
D005071 Evoked Potentials Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported. Event Related Potential,Event-Related Potentials,Evoked Potential,N100 Evoked Potential,P50 Evoked Potential,N1 Wave,N100 Evoked Potentials,N2 Wave,N200 Evoked Potentials,N3 Wave,N300 Evoked Potentials,N4 Wave,N400 Evoked Potentials,P2 Wave,P200 Evoked Potentials,P50 Evoked Potentials,P50 Wave,P600 Evoked Potentials,Potentials, Event-Related,Event Related Potentials,Event-Related Potential,Evoked Potential, N100,Evoked Potential, N200,Evoked Potential, N300,Evoked Potential, N400,Evoked Potential, P200,Evoked Potential, P50,Evoked Potential, P600,Evoked Potentials, N100,Evoked Potentials, N200,Evoked Potentials, N300,Evoked Potentials, N400,Evoked Potentials, P200,Evoked Potentials, P50,Evoked Potentials, P600,N1 Waves,N2 Waves,N200 Evoked Potential,N3 Waves,N300 Evoked Potential,N4 Waves,N400 Evoked Potential,P2 Waves,P200 Evoked Potential,P50 Waves,P600 Evoked Potential,Potential, Event Related,Potential, Event-Related,Potential, Evoked,Potentials, Event Related,Potentials, Evoked,Potentials, N400 Evoked,Related Potential, Event,Related Potentials, Event,Wave, N1,Wave, N2,Wave, N3,Wave, N4,Wave, P2,Wave, P50,Waves, N1,Waves, N2,Waves, N3,Waves, N4,Waves, P2,Waves, P50
D005971 Glutamates Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure. Glutamic Acid Derivatives,Glutamic Acids,Glutaminic Acids
D000428 Alcohol Drinking Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking. Alcohol Consumption,Alcohol Intake,Drinking, Alcohol,Alcohol Drinking Habits,Alcohol Drinking Habit,Alcohol Intakes,Consumption, Alcohol,Drinking Habit, Alcohol,Habit, Alcohol Drinking,Habits, Alcohol Drinking,Intake, Alcohol
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012646 Self Administration Administration of a drug or chemical by the individual under the direction of a physician. It includes administration clinically or experimentally, by human or animal. Administration, Self,Administrations, Self,Self Administrations
D016194 Receptors, N-Methyl-D-Aspartate A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity. N-Methyl-D-Aspartate Receptor,N-Methyl-D-Aspartate Receptors,NMDA Receptor,NMDA Receptor-Ionophore Complex,NMDA Receptors,Receptors, NMDA,N-Methylaspartate Receptors,Receptors, N-Methylaspartate,N Methyl D Aspartate Receptor,N Methyl D Aspartate Receptors,N Methylaspartate Receptors,NMDA Receptor Ionophore Complex,Receptor, N-Methyl-D-Aspartate,Receptor, NMDA,Receptors, N Methyl D Aspartate,Receptors, N Methylaspartate
D017072 Neostriatum The phylogenetically newer part of the CORPUS STRIATUM consisting of the CAUDATE NUCLEUS and PUTAMEN. It is often called simply the striatum.
D017447 Receptors, Dopamine D1 A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D1-class receptor genes lack INTRONS, and the receptors stimulate ADENYLYL CYCLASES. Dopamine D1 Receptors,Dopamine-D1 Receptor,D1 Receptors, Dopamine,Dopamine D1 Receptor,Receptor, Dopamine-D1

Related Publications

Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
July 2017, Neurobiology of learning and memory,
Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
October 2002, The European journal of neuroscience,
Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
January 2018, eNeuro,
Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
January 2006, The European journal of neuroscience,
Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
January 2006, Advances in experimental medicine and biology,
Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
April 1999, Journal of neurophysiology,
Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
June 1994, Current opinion in neurobiology,
Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
June 2012, Cold Spring Harbor perspectives in biology,
Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
March 2018, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
Tengfei Ma, and Yifeng Cheng, and Emily Roltsch Hellard, and Xuehua Wang, and Jiayi Lu, and Xinsheng Gao, and Cathy C Y Huang, and Xiao-Yan Wei, and Jun-Yuan Ji, and Jun Wang
January 1996, Hippocampus,
Copied contents to your clipboard!