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New penicillide derivatives isolated from Penicillium simplicissimum. 2006
Shin-Ichirou Komai, and
Tomoo Hosoe, and
Takeshi Itabashi, and
Koohei Nozawa, and
Takashi Yaguchi, and
Kazutaka Fukushima, and
Ken-Ichi Kawai
Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan.
Two new penicillide derivatives, secopenicillides A (3) and B (4), were isolated along with penicillide (1) and purpactin A (2), and altenusin (5) and dehydroaltenusin (6), the antifungal substances of this fungus, from the extract of Penicillium simplicissimum IFM 53375. The absolute structures of 3 and 4 were determined by spectroscopic investigation and chemical correlation to penicillide (1). The absolute configuration of purpactin A (2) was determined by the chemical method.
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