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To assess the physiological role of atrial natriuretic factors in blood pressure regulation, we studied the effect of chronic infusion of a synthetic atrial natriuretic factor of 25 amino acid residues (Arg 102-Tyr 126) in rats with angiotensin II-induced hypertension. Rats were studied while on a normal sodium diet or during sodium loading with 1% NaCl solution used as drinking water. Systolic blood pressure decreased slightly during combined infusion of synthetic atrial natriuretic factor, 150 micrograms/kg/day, and angiotensin II, 900 micrograms/kg/day. This effect was sustained for 3 days in rats receiving a regular sodium intake (p less than 0.01) and during sodium loading (p less than 0.01). Administration of synthetic atrial natriuretic factor to rats made hypertensive by a 3-day infusion of angiotensin II reduced blood pressure slightly, but not to control levels, and this effect was sustained for the remaining 3 days of the experiment in both dietary groups. These results indicate that a nonhypotensive dose of synthetic atrial natriuretic factor can modulate the vasopressor effect of angiotensin II. Thus, the attenuating effect may be involved in blood pressure regulation independently of sodium metabolism, although its actual physiological importance remains undetermined.
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
January 1986,
Peptides,
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
June 1989,
American journal of hypertension,
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
December 1995,
Hypertension research : official journal of the Japanese Society of Hypertension,
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
April 1992,
Sheng li xue bao : [Acta physiologica Sinica],
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
August 1990,
Journal of hypertension,
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
October 1989,
Journal of molecular and cellular cardiology,
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
May 1993,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
April 1989,
Journal of hypertension,
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
March 1988,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
M Yasujima, and
K Abe, and
M Kohzuki, and
M Tanno, and
Y Kasai, and
M Sato, and
K Omata, and
K Kudo, and
K Takeuchi, and
M Hiwatari
June 1986,
European journal of pharmacology,
