Intravenous magnesium sulfate for acute wheezing in young children: a randomised double-blind trial. 2018

Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
PEDEGO Research Unit and Medical Research Center Oulu, University of Oulu, Oulu, Finland hannele.pruikkonen@oulu.fi.

Magnesium sulfate has been shown to be an effective treatment in older children with asthma exacerbations, but it has not been investigated in acute severe virus-induced wheezing in young children.The study enrolled 61 children aged 6 months to 4 years. Inclusion criteria were severe wheezing, classified as a score of ≥6 points as assessed by the Respiratory Distress Assessment Instrument (RDAI) after initial treatment with salbutamol, and the symptoms of acute viral infection. The children were randomly allocated to receive either an infusion of magnesium sulfate (40 mg·kg-1) or 0.9% sodium chloride as a placebo infusion for 20 min. Primary outcome measure was mean change in RDAI scores from baseline to 6 h after the treatment.Change in the severity of wheezing from baseline to 6 h after the treatment, as measured by mean±sd RDAI scores, was 4.7±2.6 in the magnesium sulfate group and 4.2±4.2 in the placebo group (difference 0.5, 95% CI -1.3 to 2.3, p=0.594).Intravenous magnesium sulfate was ineffective in treating acute severe virus-induced wheezing in young children, in contrast to the previous efficacy demonstrated in older children.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008278 Magnesium Sulfate A small colorless crystal used as an anticonvulsant, a cathartic, and an electrolyte replenisher in the treatment of pre-eclampsia and eclampsia. It causes direct inhibition of action potentials in myometrial muscle cells. Excitation and contraction are uncoupled, which decreases the frequency and force of contractions. (From AMA Drug Evaluations Annual, 1992, p1083) Magnesium Sulfate, Heptahydrate,Heptahydrate Magnesium Sulfate,Sulfate, Magnesium
D008297 Male Males
D012135 Respiratory Sounds Noises, normal and abnormal, heard on auscultation over any part of the RESPIRATORY TRACT. Breathing Sounds,Crackles,Lung Sounds,Pleural Rub,Rales,Rhonchi,Stridor,Wheezing,Breathing Sound,Crackle,Lung Sound,Pleural Rubs,Rale,Respiratory Sound,Rhonchus,Rub, Pleural,Sound, Breathing,Sound, Lung,Sound, Respiratory,Sounds, Breathing,Sounds, Lung,Stridors,Wheezings
D001993 Bronchodilator Agents Agents that cause an increase in the expansion of a bronchus or bronchial tubes. Bronchial-Dilating Agents,Bronchodilator,Bronchodilator Agent,Broncholytic Agent,Bronchodilator Effect,Bronchodilator Effects,Bronchodilators,Broncholytic Agents,Broncholytic Effect,Broncholytic Effects,Agent, Bronchodilator,Agent, Broncholytic,Agents, Bronchial-Dilating,Agents, Bronchodilator,Agents, Broncholytic,Bronchial Dilating Agents,Effect, Bronchodilator,Effect, Broncholytic,Effects, Bronchodilator,Effects, Broncholytic
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004311 Double-Blind Method A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment. Double-Masked Study,Double-Blind Study,Double-Masked Method,Double Blind Method,Double Blind Study,Double Masked Method,Double Masked Study,Double-Blind Methods,Double-Blind Studies,Double-Masked Methods,Double-Masked Studies,Method, Double-Blind,Method, Double-Masked,Methods, Double-Blind,Methods, Double-Masked,Studies, Double-Blind,Studies, Double-Masked,Study, Double-Blind,Study, Double-Masked
D004417 Dyspnea Difficult or labored breathing. Orthopnea,Platypnea,Recumbent Dyspnea,Rest Dyspnea,Trepopnea,Breathlessness,Shortness of Breath,Breath Shortness,Dyspnea, Recumbent,Dyspnea, Rest,Dyspneas, Rest
D005260 Female Females
D005387 Finland A country in northern Europe, bordering the Baltic Sea, Gulf of Bothnia, and Gulf of Finland, between Sweden and Russia. The capital is Helsinki. Aland Islands,Åland Islands

Related Publications

Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
July 1995, Stroke,
Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
September 1995, Annals of the New York Academy of Sciences,
Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
January 2001, Clinical neuropharmacology,
Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
February 1987, Lancet (London, England),
Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
June 2013, The Lancet. Respiratory medicine,
Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
May 2001, Clinical pharmacology and therapeutics,
Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
July 2004, The Journal of pediatrics,
Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
December 2003, BMJ (Clinical research ed.),
Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
February 2004, Lancet (London, England),
Hannele Pruikkonen, and Terhi Tapiainen, and Merja Kallio, and Teija Dunder, and Tytti Pokka, and Matti Uhari, and Marjo Renko
January 2021, Brazilian journal of anesthesiology (Elsevier),
Copied contents to your clipboard!