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Twenty patients with chronic renal failure were studied before and after haemodialysis. Plasma atrial natriuretic peptide (ANP) concentrations were markedly elevated (P less than 0.01) before dialysis in comparison with healthy control subjects. After haemodialysis the plasma ANP concentration was lower in 19 patients (P less than 0.01) but remained above the normal range in all but three cases. Systolic and diastolic blood pressure and body weight fell during dialysis but none of these changes correlated with the reduction of the plasma ANP concentration. Chromatographic analysis of plasma extracts indicated that alpha-ANP is the predominant circulating molecular form. The increase in concentration of ANP in plasma between dialyses, at a time when many patients are susceptible to sodium and water overload, and its return towards normal after dialysis supports the putative role of ANP as a circulating factor released in response to sodium and water accumulation.
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
January 1991,
International urology and nephrology,
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
January 1986,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
August 1990,
Journal of the Formosan Medical Association = Taiwan yi zhi,
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
February 1992,
Clinical science (London, England : 1979),
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
May 1994,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
October 1986,
The Journal of clinical endocrinology and metabolism,
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
February 1987,
Clinical and experimental pharmacology & physiology,
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
September 1994,
Clinical science (London, England : 1979),
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
November 1988,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
J V Anderson, and
A E Raine, and
A Proudler, and
S R Bloom
January 1988,
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association,
