-transparent.png){kind=logo}
Concentrations of endogenous opioid peptides in the plasma are increased during exercise and these substances have been implicated in the pathogenesis of asthma induced by chloropropramide and alcohol in diabetic patients. This work was undertaken to determine whether exercise induced asthma might be mediated by endogenous opioids. Plasma beta endorphin, met-enkephalin, and adrenocorticotrophic hormone (ACTH) concentrations were measured in five asthmatic patients and five normal volunteers breathing cold air during exercise. In four of the patients the effect of an infusion of naloxone on FEV1 was also measured during exercise induced asthma. Exercise produced acute bronchoconstriction in all asthmatics, characterised by a fall in FEV1; whereas no change occurred in normal subjects. There was no difference in plasma met-enkephalin, beta endorphin, and ACTH concentration between the two groups. Infusion of naloxone neither prevented nor worsened exercise induced asthma. These data suggest that endogenous opioids probably do not play a part in the development of exercise induced asthma.
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
December 1981,
The New England journal of medicine,
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
June 1986,
The Journal of allergy and clinical immunology,
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
January 2001,
Pulmonary pharmacology & therapeutics,
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
January 1997,
Acta physiologica Scandinavica. Supplementum,
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
November 1988,
The Journal of laboratory and clinical medicine,
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
August 1990,
Sports medicine (Auckland, N.Z.),
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
September 1986,
The Veterinary record,
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
August 1986,
The Veterinary record,
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
April 2021,
Psychoneuroendocrinology,
R C Gaillard, and
M Bachman, and
T Rochat, and
D Egger, and
R de Haller, and
A F Junod
September 2010,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
