Biomaterial Database

Effect of the histamine-H2 antagonist cimetidine on meal-stimulated biliary secretion in dogs. 1986

J A Madrid, and G M Salido, and E Martínez de Victoria, and F J Mataix

In conscious dogs with a bidirectional biliary cannula we studied the effect of orally administered cimetidine (10 mg/kg) on biliary secretion in response to a standard meal. The intake of a meal induced a significant increase in the biliary flow. When cimetidine is administered before feeding, a greater biliary response was observed in both cholecystectomized and uncholecystectomized animals. Under our experimental conditions this effect could be explained by an increase in the resistance of the sphincter of Oddi together with an increase in biliary tract and gallbladder motility. On the other hand, decrease in taurocholate and increase in chloride concentrations were observed during cimetidine treatment in all dogs. Moreover cimetidine elicits a fall in bilirubin concentration in cholecystectomized animals. The changes in organic anions could be due to a reduction in portal blood flow together with an interference of cimetidine with hepatic oxidative pathways. The greater concentration of chloride could be due to a lesser release of secretin. Most of these effects were transitory because they return to control values after the end of treatment.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D002712	Chlorides	Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.	Chloride,Chloride Ion Level,Ion Level, Chloride,Level, Chloride Ion
D002763	Cholecystectomy	Surgical removal of the GALLBLADDER.	Cholecystectomies
D002927	Cimetidine	A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.	Altramet,Biomet,Biomet400,Cimetidine HCl,Cimetidine Hydrochloride,Eureceptor,Histodil,N-Cyano-N'-methyl-N''-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)guanidine,SK&F-92334,SKF-92334,Tagamet,HCl, Cimetidine,Hydrochloride, Cimetidine,SK&F 92334,SK&F92334,SKF 92334,SKF92334
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D005502	Food	Substances taken in by the body to provide nourishment.	Foods
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001646	Bile	An emulsifying agent produced in the LIVER and secreted into the DUODENUM. Its composition includes BILE ACIDS AND SALTS; CHOLESTEROL; and ELECTROLYTES. It aids DIGESTION of fats in the duodenum.	Biliary Sludge,Sludge, Biliary
D001663	Bilirubin	A bile pigment that is a degradation product of HEME.	Bilirubin IX alpha,Bilirubin, (15E)-Isomer,Bilirubin, (4E)-Isomer,Bilirubin, (4E,15E)-Isomer,Bilirubin, Calcium Salt,Bilirubin, Disodium Salt,Bilirubin, Monosodium Salt,Calcium Bilirubinate,Hematoidin,delta-Bilirubin,Bilirubinate, Calcium,Calcium Salt Bilirubin,Disodium Salt Bilirubin,Monosodium Salt Bilirubin,Salt Bilirubin, Calcium,delta Bilirubin