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To determine the effect of water deprivation (mixed volume and osmotic stimulus) on the secretion of atrial natriuretic factor (ANF) and arginine vasopressin (AVP), plasma immunoreactive ANF (IR-ANF), and plasma AVP were measured in normal conscious Sprague-Dawley rats. IR-ANF was decreased to 19.9 +/- 3.6 pg/ml (24 h dehydration), 9.8 +/- 2.5 pg/ml (48 h dehydration), and undetectable level (72 h dehydration) from the control level of 62.4 +/- 2.4 pg/ml. These decreases were accompanied by significant increase in plasma AVP, serum Na+, osmolality (osm), and hematocrit (Hct). In animals deprived of water for 3 days the secretion of ANF and AVP was monitored at seven time points during the 1st h after voluntary rehydration with tap water. After rehydration, IR-ANF was elevated dramatically within 3 min and gradually for up to 1 h after water was offered; AVP decreased within 3 min of rehydration and stayed at the water-repleted level during the next 1 h. Na+, osm, and Hct did not change until 15, 9, and 30 min after rehydration, respectively. The rapid modifications in plasma IR-ANF and AVP were accompanied by a transient but significant increase in arterial blood pressure for up to 15 min after water consumption. These results indicate that oropharyngeal-gastric stimuli contribute to the release of both ANF and AVP.
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
March 1985,
Neuroendocrinology,
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
September 1985,
Endocrinology,
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
February 1991,
Acta physiologica Scandinavica,
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
January 1986,
Peptides,
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
November 1986,
Japanese circulation journal,
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
January 1992,
Materia medica Polona. Polish journal of medicine and pharmacy,
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
October 1988,
The American journal of physiology,
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
October 1995,
The Journal of physiology,
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
January 1993,
Scandinavian journal of urology and nephrology,
P Januszewicz, and
G Thibault, and
J Gutkowska, and
R Garcia, and
C Mercure, and
F Jolicoeur, and
J Genest, and
M Cantin
March 1986,
Science (New York, N.Y.),
