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In vitro production of IgG and IgM from peripheral blood lymphocytes and B-cell enriched fractions was assessed in a group of Hodgkin's disease (HD) patients and normal controls using pokeweed mitogen (PWM) stimulation. Our studies demonstrated a significant (P less than 0.01) reduction in the absolute number of helper (OKT4 positive) T cells and a significant alteration in the helper/suppressor T-cell ratio (0.89 +/- 0.15) compared to normal (1.83 +/- 0.31). Results from PWM stimulation experiments demonstrated that HD patients produced significantly lower IgG (P less than 0.01) and IgM (P less than 0.01) levels than controls. Synthesis of IgM but not IgG induced by PWM was subnormal after addition to patient B-cell cultures of autologous irradiated T cells or allogeneic irradiated normal T lymphocytes. Irradiated T cells from HD patients were as effective as normal T cells in helping PWM induced IgG and IgM synthesis by normal B cells. Our results suggest that in HD impaired circulating B-cell function is partly due to T-suppressor cell activity and furthermore that B-cell subpopulations producing different immunoglobulin isotypes may either be defective or vary in their susceptibility to T-cell suppression.
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S M McLachlan, and
E A Jacobs, and
B Fail, and
S J Proctor
May 1985,
Clinical and experimental immunology,
A M Dickinson, and
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B Fail, and
S J Proctor
July 1982,
Clinical and experimental immunology,
A M Dickinson, and
S M McLachlan, and
E A Jacobs, and
B Fail, and
S J Proctor
June 1973,
Biomedicine / [publiee pour l'A.A.I.C.I.G.],
A M Dickinson, and
S M McLachlan, and
E A Jacobs, and
B Fail, and
S J Proctor
December 1981,
Immunopharmacology,
A M Dickinson, and
S M McLachlan, and
E A Jacobs, and
B Fail, and
S J Proctor
June 1973,
Cancer,
A M Dickinson, and
S M McLachlan, and
E A Jacobs, and
B Fail, and
S J Proctor
September 1981,
Clinical immunology and immunopathology,
A M Dickinson, and
S M McLachlan, and
E A Jacobs, and
B Fail, and
S J Proctor
April 1987,
Immunology and cell biology,
A M Dickinson, and
S M McLachlan, and
E A Jacobs, and
B Fail, and
S J Proctor
January 1984,
[Hokkaido igaku zasshi] The Hokkaido journal of medical science,
A M Dickinson, and
S M McLachlan, and
E A Jacobs, and
B Fail, and
S J Proctor
August 1986,
Clinical and experimental immunology,
A M Dickinson, and
S M McLachlan, and
E A Jacobs, and
B Fail, and
S J Proctor
December 1983,
Clinical and experimental immunology,
