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The interaction of a line of human breast carcinoma cells (MCF7) with basement membrane components, particularly laminin, was altered by exposure of the cells to estrogen as well as by transfection of the cells with the v-Ha-ras oncogene. In both cases, the cells show a greater ability to attach to a laminin substrate, to migrate to laminin, to grow in the presence of a basement membrane matrix, and to cross barriers of reconstituted basement membrane. These responses were associated with an increase in the expression of laminin receptors. It is postulated that the increase in the invasive behavior of the cells treated with estrogen or transfected with v-Ha-ras is related to the increased number of laminin receptors and their interaction with laminin. Estrogen had no discernible effect on the v-Ha-ras transfected cells. It appears that in the MCF7 cells, the malignant phenotype is under hormonal control and that this control is bypassed after v-Ha-ras transfection.
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
February 1987,
Proceedings of the National Academy of Sciences of the United States of America,
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
February 1991,
International journal of cancer,
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
December 1985,
Journal of cellular physiology,
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
April 1982,
Medical hypotheses,
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
February 2003,
Cancer cell international,
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
September 1979,
Biochemical and biophysical research communications,
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
November 1990,
Journal of the National Cancer Institute,
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
January 1997,
Anticancer research,
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
February 1994,
Journal of cell science,
A Albini, and
J Graf, and
G T Kitten, and
H K Kleinman, and
G R Martin, and
A Veillette, and
M E Lippman
October 1990,
Cell biology international reports,
