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Longitudinal immune studies of patients with hemophilia A were begun in 1982 by the Regional Hemophilia Center in St. Louis, Missouri. Serum samples collected from 74 participants between 1982 and 1985 were analyzed for antibody to human T-lymphotropic virus type III (HTLV-III)/lymphadenopathy-associated virus (LAV). The incidence of antibody to HTLV-III/LAV has increased significantly in this population of patients with hemophilia. Only one of eight hemophiliacs had detectable antibody before July 1982, whereas 88.7% (55/62) were positive in 1985. T-cell surface markers were markedly abnormal in seropositive hemophilia patients with decreased percentage and number of OKT4-positive cells compared with seronegative hemophiliacs and controls. Lymphoproliferative responses to mitogens and antigens were normal in seronegative hemophilia patients. Seropositive hemophiliacs, compared with seronegative hemophiliacs, had significantly decreased lymphoproliferative responses, especially to pokeweed mitogen, tetanus, and Candida stimulations. Immune studies of seven HTLV-III/LAV seropositive hemophiliacs revealed antigen unresponsiveness and decreased T4 cells 2 to 32 months prior to development of full-blown AIDS. Longitudinal immune studies from 1983-85 revealed increasing number of seropositive hemophiliacs with antigen unresponsiveness and decreased T4 cells.
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
April 1986,
Lancet (London, England),
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
May 1987,
Blood,
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
April 1986,
The New England journal of medicine,
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
January 1986,
The New England journal of medicine,
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
February 1987,
British journal of haematology,
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
May 1986,
Nederlands tijdschrift voor geneeskunde,
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
March 1986,
Ugeskrift for laeger,
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
January 1986,
JAMA,
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
May 1986,
JAMA,
A P Knutsen, and
J D Bouhasin, and
D N Lawrence, and
S T Roodman, and
K R Mueller, and
J S McDougal, and
J H Joist
November 1986,
Schweizerische medizinische Wochenschrift,
