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A phase II study of high-dose medroxyprogesterone acetate (MPA) was performed in 18 patients with advanced breast cancer. MPA was administered at a dosage of 1,200mg orally per day. Of the 15 evaluable patients, partial response was obtained in 3, minor response in 1, no change in 5 and progressive disease in 6 patients. The response rate was 20%, which was as effective as that of tamoxifen. As the responders had been previously treated with tamoxifen, the result suggested that MPA showed no cross-resistance to the latter. Eight patients (53%) experienced weight gain which, in 4 cases (27%), necessitated discontinuation of the treatment. One patient exhibited an allergic reaction and the drug was discontinued. Palpitation in 4 patients (27%), vaginal bleeding in 2 (13%), and edema in 1 (7%) were observed, but these effects were tolerable. We therefore conclude that high-dose MPA is an effective therapy for advanced breast cancer, and that further study is warranted.
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
January 1983,
Cancer chemotherapy and pharmacology,
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
September 1982,
Cancer treatment reports,
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
August 1982,
Cancer research,
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
October 1987,
Cancer treatment reports,
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
October 1983,
Cancer treatment reports,
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
June 1989,
British journal of cancer,
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
November 1985,
Gynecologic oncology,
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
September 1982,
Cancer treatment reports,
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
January 1993,
European journal of cancer (Oxford, England : 1990),
K Ueno, and
M Ogawa, and
N Horikoshi, and
K Inoue, and
T Mukaiyama, and
T Nakamura, and
Y Ito, and
K Imajo, and
H Ozeki
August 1987,
Gan to kagaku ryoho. Cancer & chemotherapy,
