-transparent.png){kind=logo}
The effect of hypoxia on the release of atrial natriuretic factor (ANF) was studied in isolated, constant-flow perfused hearts of rats and rabbits. Effluent samples were frozen pending extraction and radioimmunoassay of ANF. Hypoxia (10 min) caused a 3.9-fold (rats) and 4.6-fold (rabbits) increase of ANF release over control values. ANF release returned to control levels within 8-11 min of reoxygenation. Prolonged (20 min) hypoxia evoked further ANF release. The increase in ANF release and decrease in ventricular pressure, heart rate and coronary perfusion pressure were fully reversible, suggesting that tissues were not damaged. These results demonstrate that hypoxia induces a massive release of ANF by an as yet unexplained mechanism.
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
July 1989,
The American journal of physiology,
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
April 2001,
Regulatory peptides,
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
April 1989,
Biochemical and biophysical research communications,
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
January 1998,
Life sciences,
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
November 1988,
American heart journal,
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
January 2000,
Canadian journal of physiology and pharmacology,
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
January 1997,
Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi,
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
March 1986,
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.),
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
August 1988,
The American journal of physiology,
A J Baertschi, and
C Hausmaninger, and
R S Walsh, and
R M Mentzer, and
D A Wyatt, and
R A Pence
December 1985,
Journal of hypertension. Supplement : official journal of the International Society of Hypertension,
